ArticleNature cancer2021
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response.
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Article in Nature cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
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Who cites it
45 citing papers in PubMed, 72 citations in OpenAlex.
- The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation.Blood cancer journal · 2022Trial
- Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.Leukemia · 2022Trial
- Viral mimicry escape as a necessary feature of malignant transformation.Nature reviews. Cancer · 2026Review
- Argonaute 2 drives resistance to immune checkpoint inhibitors in immunorefractory non-small cell lung cancer.PLoS biology · 2026Article
- Betrixaban activates cGAS-STING to promote antitumor immunity without pathological inflammation.EMBO molecular medicine · 2026Article
- Transposable elements in hematopoietic stem cells upon aging and myeloid malignancies.Mobile DNA · 2026Review
- DNMT3A in cancer: from epigenetic writer to oncogenic driver.Clinical epigenetics · 2026Review
- Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.Cell reports. Medicine · 2026Article
- Molecular basis for the inhibition of de novo DNA methylation by TCL1A.Nature communications · 2026Article
- Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review).International journal of oncology · 2026Review
- Article
- Revisiting Clonal Evolution Through the Light of Retrotransposons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Assessment of peripheral blood DNA methylation signatures as pharmacodynamic and predictive biomarkers during azacitidine therapy in juvenile myelomonocytic leukaemia: Results of the EWOG-MESRAT study.British journal of haematology · 2025Article
- A molecular-based risk score for predicting leukemia-free survival in adult AML patients undergoing Allo-HSCT.iScience · 2025Article
- Article
- Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation.Nature · 2025Article
- Significance of targeting DNMT3A mutations in AML.Annals of hematology · 2025Review
- Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Getting the right combination to break the epigenetic code.Nature reviews. Clinical oncology · 2025Review
- Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting.American journal of hematology · 2025Review
Corrections and comments
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Authors and funding
29 authors at 9 institutions in 1 country.
Marina SchellerDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany. marina.scheller@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-6108-0831
Anne Kathrin LudwigDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Stefanie GöllnerDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Christian RohdeDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Stephen KrämerBioinformatics and Omics Data Analytics Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sina StäbleSection Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5962-2440
Maike JanssenDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
James-Arne MüllerDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Lixiazi HeDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5279-7352
Nicole BäumerDepartment of Medicine A, University Hospital Münster, Münster, Germany.
Christian ArnoldEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Joachim GerßInstitute of Biostatistics and Clinical Research, WWU Münster, Münster, Germany.
Maximilian SchönungSection Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9778-9698
Christian ThiedeDepartment of Medicine, University Hospital Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0003-1241-2048
Christian NiederwieserInterdisziplinäre Klinik und Poliklinik für Stammzelltransplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-0114-1011
Dietger NiederwieserDepartment of Medicine I, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-4737-1103
Hubert ServeDepartment of Medicine II, University of Frankfurt, Frankfurt, Germany.
Wolfgang E BerdelDepartment of Medicine A, University Hospital Münster, Münster, Germany.
Ulrich ThiemGeriatrics and Gerontology, University of Hamburg, Hamburg, Germany.ORCID http://orcid.org/0000-0002-2181-6872
Inga HemmerlingDepartment of Medicine, Cardiology, University Hospital of Heidelberg, Heidelberg, Germany.
Florian LeuschnerDepartment of Medicine, Cardiology, University Hospital of Heidelberg, Heidelberg, Germany.
Christoph PlassDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias SchlesnerBioinformatics and Omics Data Analytics Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5896-4086
Judith ZauggMolecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL), University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8324-4040
Michael D MilsomDivision of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3567-254X
Andreas TrumppHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6212-3466
Caroline PabstDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9716-5909
Daniel B LipkaSection Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5081-7869
Carsten Müller-TidowDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany. carsten.mueller-tidow@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-7166-5232
Heidelberg University · DEGerman Cancer Research Center · DEEuropean Molecular Biology Organization · DEUniversität Hamburg · DEUniversity Hospital Münster · DEUniversity of Augsburg · DEEuropean Molecular Biology Laboratory · DEGoethe University Frankfurt · DEUniversity Hospital Leipzig · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatic mutations in DNA methyltransferase 3A (DNMT3A) are among the most frequent alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML), with a hotspot in exon 23 at arginine 882 (DNMT3A
Indexed as
DNA (Cytosine-5-)-MethyltransferasesLeukemia, Myeloid, AcuteAnimalsAzacitidineClonal HematopoiesisDNA Methyltransferase 3AHematopoietic Stem CellsMiceMutationAzacitidineDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.