Evidence map›Paper›PMID 35121998›Full record

ReviewNature cancer2022

The current landscape of immunotherapy for pediatric brain tumors.

Eugene I Hwang, Elias J Sayour, Catherine T Flores, Gerald Grant, Robert Wechsler-Reya, Lan B Hoang-Minh, Mark W Kieran, Joanne Salcido, Robert M Prins, John W Figg and 8 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  5. Article
  6. Article
  7. Review
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  9. Article
  10. The T cell receptor landscape of childhood brain tumors.Science translational medicine · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 2 countries.

Eugene I HwangDivision of Oncology, Brain Tumor Institute, Children's National Hospital, Washington, DC, USA. ehwang@childrensnational.org.ORCID http://orcid.org/0000-0002-3923-1135
Elias J SayourDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.
Catherine T FloresDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.
Gerald GrantDivision of Pediatric Neurosurgery, Lucile Packard Children's Hospital, Stanford University, Palo Alto, CA, USA.
Robert Wechsler-ReyaTumor Initiation & Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7463-8352
Lan B Hoang-MinhDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.
Mark W KieranDay One Biopharmaceuticals, San Francisco, CA, USA.
Joanne SalcidoBrain Tumor Foundation, Ashville, NC, USA.
Robert M PrinsDepartments of Neurosurgery and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6282-6583
John W FiggDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.
Michael PlattenDepartment of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University and CCU Brain Tumor Immunology, DKFZ, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4746-887X
Kate M CandelarioDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-2290-2657
Paul G HaleChildren's Brain Trust, Coral Springs, FL, USA.
Jason E BlattDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-6892-7724
Lance S GovernaleDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.
Hideho OkadaDepartment of Neurosurgery, University of California, San Francisco, CA, USA.
Duane A MitchellDepartment of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.
Ian F PollackDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Florida · USChildren's National · USChildren's Trust · USHeidelberg University · DELucile Packard Children's Hospital · USNGM Biopharmaceuticals (United States) · USPediatric Brain Tumor Foundation · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric central nervous system tumors are the most common solid malignancies in childhood, and aggressive therapy often leads to long-term sequelae in survivors, making these tumors challenging to treat. Immunotherapy has revolutionized prospects for many cancer types in adults, but the intrinsic complexity of treating pediatric patients and the scarcity of clinical studies of children to inform effective approaches have hampered the development of effective immunotherapies in pediatric settings. Here, we review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsChildHumansImmunologic FactorsImmunotherapySurvivorsImmunologic Factors

Identifiers

PMID35121998
OpenAlexW4206605578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.