ArticleNature cancer2020
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes.
Registry-linked trialAbstract read
In one paragraph
Article in Nature cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05132244 (Pancreatic Cancer Glucose Assessment and Regulation Study), which is not on this map. Cited by 113 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pancreatic Cancer Glucose Assessment and Regulation Study
Who cites it
113 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- The prevalence of pathogenic variants in the BMPR2 gene in patients with the idiopathic pulmonary arterial hypertension in the Russian population: sequencing data and meta-analysis.Respiratory research · 2025Pooled it
- A Large-Scale Meta-Analysis Reveals Positive Feedback between Macrophages and T Cells That Sensitizes Tumors to Immunotherapy.Cancer research · 2024Pooled it
- Plasma versus Tissue Tumor Mutational Burden as Biomarkers of Durvalumab plus Tremelimumab Response in Patients with Metastatic Colorectal Cancer in the CO.26 Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Trial
- Article
- Clinically observed RASA1 missense mutants exhibit diverse RasGAP protein behaviors in vitro.The Journal of biological chemistry · 2026Article
- Liquid Biopsy-Based Metabolomics in Epithelial Ovarian Cancer: Challenges, Methodological Advances and Translational Considerations.Diagnostics (Basel, Switzerland) · 2026Review
- The cumulative impact of passenger mutations on cancer development.Nature communications · 2026Article
- Integrative multi-omics profiling reveals distinct evolutionary and immunogenic features of brain oligometastasis in lung adenocarcinoma.Genome medicine · 2026Article
- Article
- Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types.Nature genetics · 2026Article
- Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrating liquid biopsy and mutational signatures to advance precision oncology.NPJ precision oncology · 2026Review
- PKC-eta promotes breast cancer metastasis by regulating the Hippo-YAP signaling pathway.Signal transduction and targeted therapy · 2026Article
- Integrative analyses of metastatic cancer transcriptome reveal clinically distinct cellular States and ecosystems.Scientific reports · 2026Article
- CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.Cell reports. Medicine · 2026Article
- The natural L370F ERα variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells.Cell communication and signaling : CCS · 2026Article
- Single-cell analysis of matched FFPE and frozen tissue samples reveals comparable resolution of intratumoural heterogeneity.Frontiers in genetics · 2026Article
- Predictive and prognostic value of genetic aberrations of EGFR-TKI treatment: a real-world analysis ofJournal of thoracic disease · 2025Article
- Pathologist-initiated whole genome and transcriptome sequencing demonstrates diagnostic utility in resolving difficult-to-diagnose tumors.Genome medicine · 2025Article
- OncoMark: a high-throughput neural multi-task learning framework for comprehensive cancer hallmark quantification.Communications biology · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
71 authors at 6 institutions in 1 country.
Erin Pleasance *Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Emma Titmuss *Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Laura Williamson *Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Harwood KwanCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Luka CulibrkCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Eric Y ZhaoCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Katherine DixonDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Kevin FanCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Reanne BowlbyCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Martin R JonesCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-9636-376X
Yaoqing ShenCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Jasleen K GrewalCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Jahanshah AshkaniCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Kathleen WeeCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Cameron J GrisdaleCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
My Linh ThibodeauCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Zoltan BozokyCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Hillary PearsonDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Elisa MajounieCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Tariq ViraCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Reva ShenwaiCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Karen L MungallCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Eric ChuahCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Anna DaviesCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Mya WarrenCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Caralyn ReisleCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-4318-4626
Melika BonakdarCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Gregory A TaylorCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Veronika CsizmokCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Simon K ChanCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Zusheng ZongCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Steve BilobramCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Amir MuhammadzadehCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Darryl D'SouzaCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Richard D CorbettCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Daniel MacMillanCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Marcus CarreiraCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Caleb ChooCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Dustin BleileCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Sara SadeghiCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Wei ZhangCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Tina WongCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Dean ChengCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Scott D BrownCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Robert A HoltCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Richard A MooreCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Andrew J MungallCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-0905-2742
Yongjun ZhaoCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Jessica NelsonCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Alexandra FokCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Yussanne MaCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.
Michael K C LeeDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Jean-Michel LavoieDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Shehara MendisDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Joanna M KarasinskaPancreas Centre BC, Vancouver, British Columbia, Canada.
Balvir DeolDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Ana FisicDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
David F SchaefferPancreas Centre BC, Vancouver, British Columbia, Canada.
Stephen YipDepartment of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-8514-9861
Kasmintan SchraderDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Dean A RegierCanadian Centre for Applied Research in Cancer Control, Cancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-8876-0511
Deirdre WeymannCanadian Centre for Applied Research in Cancer Control, Cancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.
Stephen ChiaDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Karen GelmonDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Anna TinkerDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Sophie SunDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Howard LimDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Daniel J RenoufDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Janessa LaskinDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Steven J M JonesCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-3394-2208
Marco A MarraCanada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada. mmarra@bcgsc.ca.ORCID http://orcid.org/0000-0001-7146-7175
Canada's Michael Smith Genome Sciences Centre · CAUniversity of British Columbia · CABC Cancer Agency · CACanadian Centre for Applied Research in Cancer Control · CAPancreas Centre (Canada) · CAVancouver General Hospital · CA
Funding
CIHR FDN 143288
Abstract
Advanced and metastatic tumors with complex treatment histories drive cancer mortality. Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and clinical dataset, amenable for exploration of the impacts of therapies on genomic landscapes. Previous exposure to DNA-damaging chemotherapies and mutations affecting DNA repair genes, including POLQ and genes encoding Polζ, were associated with genome-wide, therapy-induced mutagenesis. Exposure to platinum therapies coincided with signatures SBS31 and DSB5 and, when combined with DNA synthesis inhibitors, signature SBS17b. Alterations in ESR1, EGFR, CTNNB1, FGFR1, VEGFA and DPYD were consistent with drug resistance and sensitivity. Recurrent noncoding events were found in regulatory region hotspots of genes including TERT, PLEKHS1, AP2A1 and ADGRG6. Mutation burden and immune signatures corresponded with overall survival and response to immunotherapy. Our data offer a rich resource for investigation of advanced cancers and interpretation of whole-genome and transcriptome sequencing in the context of a cancer clinic.
Indexed as
NeoplasmsHumans
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT05132244ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.