Observational studyNature cancer2021
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study.
Registry-linked trialAbstract readObservational Study
In one paragraph
Observational study in Nature cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03226886 (TRACERx Renal), which is not on this map. Cited by 82 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRACERx Renal (TRAcking Renal Cell Carcinoma Evolution Through Therapy (Rx)) CAPTURE: COVID-19 Antiviral Response in a Pan-tumour Immune Study
Who cites it
82 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- Immunogenicity and risks associated with impaired immune responses following SARS-CoV-2 vaccination and booster in hematologic malignancy patients: an updated meta-analysis.Blood cancer journal · 2022Pooled it
- A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies.International immunopharmacology · 2022Pooled it
- Effectiveness, immunogenicity, and safety of COVID-19 vaccines for individuals with hematological malignancies: a systematic review.Blood cancer journal · 2022Pooled it
- Immunogenicity of COVID-19 vaccines in patients with diabetes mellitus: A systematic review.Frontiers in immunology · 2022Pooled it
- Long-term immune response to mRNA anti-SARS-CoV-2 vaccination in patients with cancer.Frontiers in immunology · 2026Trial
- Natural immunity to SARS-CoV-2 and breakthrough infections in vaccinated and unvaccinated patients with cancer.British journal of cancer · 2022Trial
- COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study.The Journal of infectious diseases · 2026Article
- Neutralizing antibody responses to the primary series of a COVID-19 mRNA vaccine in the cancer cohort under active treatment.Human vaccines & immunotherapeutics · 2025Article
- Delayed but successful development of immune memory against SARS-COV-2 after B cell-depleting monotherapy.Infection · 2025Observational
- Humoral and Cellular Immune Responses to SARS-CoV-2 in Participants with Head and Neck Cancer.Viruses · 2025Article
- Evaluating the impact of COVID-19 on cancer care: a comprehensive analysis of treatment modifications, risk factors, and patient outcomes.BMC infectious diseases · 2025Article
- Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination.NPJ vaccines · 2025Article
- Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy.Frontiers in immunology · 2025Article
- Impact of chemotherapy on humoral and cellular immune responses to COVID-19 vaccination in patients with solid tumors.Frontiers in immunology · 2025Article
- Immune response dynamics of SARS-CoV-2 vaccination in chronic lymphocytic leukemia individuals: a descriptive analysis.Frontiers in immunology · 2025Article
- Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures.International journal of molecular sciences · 2024Article
- Factors Predicting COVID-19 Vaccine Effectiveness and Longevity of Humoral Immune Responses.Vaccines · 2024Review
- Article
- Global seroprevalence of neutralizing antibodies against adeno-associated virus serotypes used for human gene therapies.Molecular therapy. Methods & clinical development · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
98 authors.
Annika Fendler *Cancer Dynamics Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-7267-0981
Scott T C Shepherd *Cancer Dynamics Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-6208-173X
Lewis Au *Cancer Dynamics Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-5877-8657
Katalin A Wilkinson *Tuberculosis Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-9796-2040
Mary Wu *High Throughput Screening Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-2074-6171
Fiona ByrneCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Maddalena CerroneTuberculosis Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6900-6086
Andreas M SchmittSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Nalinie Joharatnam-HoganSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Benjamin ShumCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Zayd TippuSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Karolina RzeniewiczCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Laura Amanda BoosSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-4287-799X
Ruth HarveyWorldwide Influenza Centre, the Francis Crick Institute, London, UK.
Eleanor CarlyleSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Kim EdmondsSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Lyra Del RosarioSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Sarah SarkerSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Karla LingardSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Mary MangwendeSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Lucy HoltSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Hamid AhmodSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Justine KortewegSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Tara FoleySkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Jessica BazinHaemato-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
William GordonCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-8166-2641
Taja BarberCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Andrea Emslie-HenryCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Wenyi XieCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Camille L GerardCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Daqi DengCancer Dynamics Laboratory, the Francis Crick Institute, London, UK.
Emma C WallUniversity College London Hospitals NHS Foundation Trust Biomedical Research Centre, London, UK.ORCID http://orcid.org/0000-0003-2732-4497
Ana Agua-DoceFlow Cytometry Scientific Technology Platform, the Francis Crick Institute, London, UK.
Sina NamjouSafety, Health & Sustainability, the Francis Crick Institute, London, UK.
Simon CaidanSafety, Health & Sustainability, the Francis Crick Institute, London, UK.
Mike GavrielidesScientific Computing Scientific Technology Platform, the Francis Crick Institute, London, UK.
James I MacRaeMetabolomics Scientific Technology Platform, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1464-8583
Gavin KellyDepartment of Bioinformatics and Biostatistics, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-7219-560X
Kema PeatSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Denise KellySkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Aida MurraSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Kayleigh KellySkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Molly O'FlahertySkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Lauren DowdieSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Natalie AshSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Firza GronthoudDepartment of Pathology, the Royal Marsden NHS Foundation Trust, London, UK.
Robyn L SheaDepartment of Pathology, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-7596-4555
Gail GardnerDepartment of Pathology, the Royal Marsden NHS Foundation Trust, London, UK.
Darren MurrayDepartment of Pathology, the Royal Marsden NHS Foundation Trust, London, UK.
Fiona KinnairdClinical Trials Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Wanyuan CuiLung Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-5077-6814
Javier PascualBreast Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-3874-2782
Simon RodneySkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Justin MencelGastrointestinal Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-1097-7953
Olivia CurtisLung Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-1509-7023
Clemency StephensonHaemato-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Anna RobinsonHaemato-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Bhavna OzaSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Sheima FaragSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Isla LeslieSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Aljosja RogiersSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Sunil IyengarHaemato-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Mark EthellHaemato-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Christina MessiouDepartment of Radiology, the Royal Marsden NHS Foundation Trust, London, UK.
David CunninghamGastrointestinal Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0001-5158-1069
Ian ChauGastrointestinal Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-0286-8703
Naureen StarlingGastrointestinal Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Nicholas TurnerBreast Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Liam WelshNeuro-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Nicholas van AsClinical Oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Robin L JonesSarcoma Unit, the Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK.
Joanne DroneyPalliative Medicine, the Royal Marsden NHS Foundation Trust, London, UK.
Susana BanerjeeGynaecology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Kate C TathamAnaesthetics, Perioperative Medicine and Pain Department, the Royal Marsden NHS Foundation Trust, London, UK.
Mary O'BrienLung Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Kevin HarringtonHead and Neck Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Shreerang BhideHead and Neck Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Alicia OkinesBreast Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Alison ReidUro-oncology Unit, the Royal Marsden NHS Foundation Trust, Surrey, UK.
Kate YoungSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Andrew J S FurnessSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Lisa PickeringSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-7579-340X
Charles SwantonCancer Evolution and Genome Instability Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-4299-3018
Crick COVID-19 Consortium
Sonia GandhiNeurodegeneration Biology Laboratory, the Francis Crick Institute, London, UK.
Steve GamblinStructural Biology of Disease Processes Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-5331-639X
David L V BauerRNA Virus Replication Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-3052-0368
George KassiotisRetroviral Immunology Laboratory, the Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-8457-2633
Sacheen KumarGastrointestinal Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-4692-4554
Nadia YousafLung Unit, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-2090-0025
Shaman JhanjiAnaesthetics, Perioperative Medicine and Pain Department, the Royal Marsden NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-1116-628X
Emma NicholsonHaemato-oncology Unit, the Royal Marsden NHS Foundation Trust, London, UK.
Michael HowellHigh Throughput Screening Laboratory, the Francis Crick Institute, London, UK.
Susanna WalkerAnaesthetics, Perioperative Medicine and Pain Department, the Royal Marsden NHS Foundation Trust, London, UK.
Robert J WilkinsonTuberculosis Laboratory, the Francis Crick Institute, London, UK.
James LarkinSkin and Renal Units, the Royal Marsden NHS Foundation Trust, London, UK.
Samra TurajlicCancer Dynamics Laboratory, the Francis Crick Institute, London, UK. samra.turajlic@crick.ac.uk.ORCID http://orcid.org/0000-0001-8846-136X
CAPTURE Consortium
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80% of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic.
Indexed as
AgedAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineChAdOx1 nCoV-19COVID-19FemaleHumansImmunity, CellularImmunogenicity, VaccineMaleMiddle AgedNeoplasmsProspective StudiesSARS-CoV-2T-LymphocytesAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineChAdOx1 nCoV-19
Identifiers
PMID
35121899What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT03226886ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.