ArticleScientific reports2022
Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- A 12-lead or 10-lead electrocardiogram in cats? An analysis comparing 6-lead and 4-lead precordial systems.Open veterinary journal · 2026Article
- Assessment of arrhythmias in healthy cats using 24-hour Holter monitoring: a cross-sectional study.BMC veterinary research · 2026Article
- Association between ultra-short-term heart rate variability of time fluctuation and atrial fibrillation: Evidence from MIMIC-IV.Heart rhythm O2 · 2025Article
- Evaluating heart rate variability by a novel stethoscopic approach to minimise stress in cats.Journal of feline medicine and surgery · 2024Article
- The Unseen Side of Feline Hypertrophic Cardiomyopathy: Diagnostic and Prognostic Utility of Electrocardiography and Holter Monitoring.Animals : an open access journal from MDPI · 2024Review
- A novel approach for contactless heart rate monitoring from pet facial videos.Frontiers in veterinary science · 2024Article
- Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease.Scientific reports · 2023Article
- Parasympathetic tone activity, heart rate, and grimace scale in conscious horses of 3 breeds before, during, and after nociceptive mechanical stimulation.Journal of veterinary internal medicineArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utility of ambulatory electrocardiography (AECG) to evaluate cats with subclinical hypertrophic cardiomyopathy (HCM) for arrhythmias and heart rate variability (HRV) is not well defined but may provide information regarding risk stratification. This prospective study used AECG to evaluate ectopy and HRV in subclinical HCM cats compared to healthy controls and is the first to implement a pharmacologic cardiac stress test. Twenty-three purpose-bred, Maine coon cross cats (16 HCM, 7 control) underwent 48-h of continuous AECG. Terbutaline (0.2-0.3 mg/kg) was administered orally at 24 and 36 h. Heart rate, ectopy frequency and complexity and HRV parameters, including standard deviation of normal R-R intervals (SDNN), were compared pre-terbutaline and post-terbutaline and across phenotype, genotype and sex. Genotype for an HCM-causative mutation was significantly associated with the frequency of supraventricular (P = 0.033) and ventricular (P = 0.026) ectopy across all cats. Seven HCM cats and zero healthy cats had a sinus arrhythmia. Mean heart rate was significantly higher post-terbutaline (p < 0.0001). HCM cats had significantly greater HRV compared to controls (SDNN: p = 0.0006). Male cats had significantly higher HRV (SDNN: p = 0.0001) and lower mean heart rates (p = 0.0001). HRV decreased post-terbutaline (SDNN: p = 0.0008) and changes in HRV observed between sexes were attenuated by terbutaline.
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