ArticleNeurology2022
Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis.
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Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30citing papers in PubMed, 1 pooled it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Clinical, Radiological, and Immunohistological Distinctions Between Limbic-Predominant and Typical Alzheimer's Disease: A Systematic Review.Brain and behavior · 2026Pooled it
- Post mortem MRI of cholinergic white matter pathways across neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Effects of concurrent neuropathologies with Alzheimer disease neuropathologic change on cognitive decline: Minimal impact of vascular brain injury compared with other combinations.Journal of neuropathology and experimental neurology · 2026Article
- Characterizing the MRI signature of hippocampal sclerosis of aging.Alzheimer's research & therapy · 2026Article
- Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE).Acta neuropathologica · 2026Review
- Alzheimer mimicry: LATE and PART.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults.JAMA network open · 2025Article
- Common neuropathologic change drivers of hippocampal sclerosis of ageing.Brain : a journal of neurology · 2025Article
- Unraveling the clinical-pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer's Coordinating Center dataset.Journal of neuropathology and experimental neurology · 2025Article
- Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes.Journal of neuropathology and experimental neurology · 2025Article
- The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Decoding TDP-43: the molecular chameleon of neurodegenerative diseases.Acta neuropathologica communications · 2024Review
- Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC.Journal of molecular neuroscience : MN · 2024Article
- Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database.Acta neuropathologica · 2024Article
- Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis.Journal of neuropathology and experimental neurology · 2024Review
- Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies.Acta neuropathologica · 2024Article
- Amidst an amygdala renaissance in Alzheimer's disease.Brain : a journal of neurology · 2024Article
- Clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome.Brain communications · 2024Article
- Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease.Journal of neuropathology and experimental neurology · 2023Article
- A limbic-predominant amnestic neurodegenerative syndrome associated with TDP-43 pathology.medRxiv : the preprint server for health sciences · 2023Article
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Authors and funding
13 authors at 1 institution in 2 countries.
Kathryn M GauthreauxFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Merilee A TeylanFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Yuriko KatsumataFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Charles MockFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Jessica E CulhaneFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Yen-Chi ChenFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Kwun C G ChanFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
David W FardoFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Adam J DuganFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.ORCID 0000-0001-5783-3781
Matthew D CykowskiFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.ORCID 0000-0002-5973-803X
Gregory A JichaFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Walter A KukullFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington.
Peter T NelsonFrom the National Alzheimer's Coordinating Center (K.M.G., M.A.T., C.M., J.E.C., K.C.G.C., W.A.K.), Department of Epidemiology, and Department of Statistics (Y.-C.C.) University of Washington, Seattle; Houston Methodist Hospital (M.D.C.), TX; and Sanders-Brown Center on Aging (Y.K., D.W.F., G.A.J., P.T.N.), Department of Biostatistics (Y.K., D.W.F., A.J.D.), Department of Neurology (G.A.J.), and Department of Pathology (P.T.N.), Division of Neuropathology, University of Kentucky, Lexington. pnels2@email.uky.edu.
University of Washington · US
Funding
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MVIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MSatellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0MTHE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0MVESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GROSSMAN, HILLEL · 1985 to 2019
$37.9M'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6MNIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG054060NIA NIH HHS R01 AG057187NIA NIH HHS R01 AG061111NIA NIH HHS R56 AG057191NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122NINDS NIH HHS RF1 NS118584
Abstract
BACKGROUND AND
objectivesLimbic-predominant age-related Tar DNA binding protein 43 (TDP-43) encephalopathy neuropathologic change (LATE-NC) is present in ≈25% of older persons' brains and is strongly associated with cognitive impairment. Hippocampal sclerosis (HS) pathology is often comorbid with LATE-NC, but the clinical and pathologic correlates of HS in LATE-NC are not well understood.
methodsThis retrospective autopsy cohort study used data derived from the National Alzheimer's Coordinating Center Neuropathology Data Set, which included neurologic status, medical histories, and neuropathologic results. All autopsies were performed in 2014 or later. Among participants with LATE-NC, those who also had HS pathology were compared with those without HS with regard to candidate risk factors or common underlying diseases. Statistical significance was set at nominal
resultsA total of 408 participants were included (n = 221 were LATE-NC+/HS-, n = 145 were LATE-NC+/HS+, and n = 42 were LATE-NC-/HS+). Most of the included LATE-NC+ participants were severely impaired cognitively (83.3% with dementia). Compared to HS- participants, LATE-NC+ participants with HS trended toward having worse cognitive status and scored lower on the Personal Care and Orientation domains (both DISCUSSION: In this cohort skewed toward participants with severe dementia, LATE-NC+ HS pathology was not associated with seizures or with Alzheimer-type pathologies. Rather, the presence of comorbid HS pathology was associated with more widespread TDP-43 proteinopathy and with more severe non-β-amyloid vessel wall pathologies.
Indexed as
Alzheimer DiseaseTDP-43 ProteinopathiesAgedAged, 80 and overCohort StudiesDNA-Binding ProteinsHippocampusHumansRetrospective StudiesSclerosisDNA-Binding Proteins
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