ArticleNeurology2022
Cognitive Reserve and Mild Cognitive Impairment: Predictors and Rates of Reversion to Intact Cognition vs Progression to Dementia.
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 62 citations in OpenAlex.
- Cognitive reserve and everyday functioning in cognitively unimpaired older adults: evidence from the CAN-PROTECT study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Association Between Cognitively Stimulating Activities and Cognitive Function in Older Adults Living in Residential Care Homes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression.Nature communications · 2026Article
- Longitudinal Trajectories of Cognitive Control and Theory of Mind in Amnestic and Non-Amnestic Mild Cognitive Impairment: Prospective Associations of Objective Sleep Duration.Journal of clinical medicine · 2026Article
- Effectiveness of Multisensory Stimulation on Cognitive Function in Older Adults With Mild Cognitive Impairment: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- The current status and implications of aging research from a health perspective.Frontiers in psychology · 2026Review
- Association Rule Analysis of Cognitive Frailty Subtypes in Community-Dwelling Older Adults.Clinical interventions in aging · 2026Article
- Associations between cognitive reserve, iron deposition in the basal ganglia, and cognitive function in mild cognitive impairment.Frontiers in psychology · 2026Article
- Predictors of Transition from Mild Cognitive Impairment to Normal Cognition and Dementia.Behavioral sciences (Basel, Switzerland) · 2025Article
- Sleep Trajectories in Amnestic and Non-Amnestic MCI: Longitudinal Insights from Subjective and Objective Assessments.Diagnostics (Basel, Switzerland) · 2025Article
- Predictors of transitions between normal cognition, cognitive impairment, and dementia in a longitudinal cohort.Journal of Alzheimer's disease : JAD · 2025Article
- Article
- Regional disparities in cognitive life expectancy: The role of birth and current residence in the United States.Health & place · 2025Article
- Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.BMC psychiatry · 2025Article
- Coping with cognitive decline in older adults with mild cognitive impairment or mild dementia: a scoping review.Aging & mental health · 2025Article
- Characterizing bidirectional transitions in mild cognitive impairment and post-reversion based on longitudinal neuroimaging and cognitive assessments.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Prenatal immune origins of brain aging differ by sex.Molecular psychiatry · 2025Article
- The Nun Study: Insights from 30 years of aging and dementia research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesLittle is known about the effect of education or other indicators of cognitive reserve on the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) or the relative rate (RR) of reversion from MCI to NC vs progression from MCI to dementia. Our objectives were to (1) estimate transition rates from MCI to NC and dementia and (2) determine the effect of age,
methodsWe estimated instantaneous transition rates between NC, MCI, and dementia after accounting for transition to death across up to 12 assessments in the Nun Study, a cohort study of religious sisters aged 75+ years. We estimated RRs of reversion vs progression for age,
resultsOf the 619 participants, 472 were assessed with MCI during the study period. Of these 472, 143 (30.3%) experienced at least one reverse transition to NC, and 120 of the 143 (83.9%) never developed dementia (mean follow-up = 8.6 years). In models adjusted for age group and DISCUSSION: Knowledge of frequent reversion from MCI to NC may alleviate concerns of inevitable cognitive decline in those with MCI. Identification of characteristics predicting the rate of reversion from MCI to NC vs progression from MCI to dementia may guide population-level interventions targeting these characteristics to prevent or postpone MCI and dementia. Research on cognitive trajectories would benefit from incorporating predictors of reverse transitions and competing events, such as death, into statistical modeling. These results may inform the design and interpretation of MCI clinical trials, given that a substantial proportion of participants may experience improvement without intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.