Evidence map›Paper›PMID 35121666›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Toward a theory of evolution as multilevel learning.

Vitaly Vanchurin, Yuri I Wolf, Mikhail I Katsnelson, Eugene V Koonin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Review
  3. Geometric Learning Dynamics.Biological cybernetics · 2026
    Article
  4. The selfish ribosome.PLoS biology · 2026
    Article
  5. Heuristically Adaptive Diffusion-Model Evolutionary Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Bifurcations and phase transitions in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  12. Generalizing the central dogma as a cross-hierarchical principle of biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  13. Dataset-Learning Duality and Emergent Criticality.Entropy (Basel, Switzerland) · 2025
    Article
  14. Implications From the Analogous Relationship Between Evolutionary and Learning Processes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Control of Overfitting with Physics.Entropy (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vitaly VanchurinNational Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894; vitaly.vanchurin@gmail.com koonin@ncbi.nlm.nih.gov.
Yuri I WolfNational Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894.ORCID 0000-0002-0247-8708
Mikhail I KatsnelsonInstitute for Molecules and Materials, Radboud University, Nijmegen 6525AJ, The Netherlands.ORCID 0000-0001-5165-7553
Eugene V KooninNational Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894; vitaly.vanchurin@gmail.com koonin@ncbi.nlm.nih.gov.ORCID 0000-0003-3943-8299

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We apply the theory of learning to physically renormalizable systems in an attempt to outline a theory of biological evolution, including the origin of life, as multilevel learning. We formulate seven fundamental principles of evolution that appear to be necessary and sufficient to render a universe observable and show that they entail the major features of biological evolution, including replication and natural selection. It is shown that these cornerstone phenomena of biology emerge from the fundamental features of learning dynamics such as the existence of a loss function, which is minimized during learning. We then sketch the theory of evolution using the mathematical framework of neural networks, which provides for detailed analysis of evolutionary phenomena. To demonstrate the potential of the proposed theoretical framework, we derive a generalized version of the Central Dogma of molecular biology by analyzing the flow of information during learning (back propagation) and predicting (forward propagation) the environment by evolving organisms. The more complex evolutionary phenomena, such as major transitions in evolution (in particular, the origin of life), have to be analyzed in the thermodynamic limit, which is described in detail in the paper by Vanchurin et al. [V. Vanchurin, Y. I. Wolf, E. V. Koonin, M. I. Katsnelson,

Indexed as

Biological EvolutionLearningModels, BiologicalSelection, GeneticThermodynamicsloss functionmajor evolutionary transitionsnatural selectionorigin of lifetheory of learning

Identifiers

PMID35121666
PMCPMC8833143

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.