ArticleProceedings of the National Academy of Sciences of the United States of America2022
Topographically organized representation of space and context in the medial prefrontal cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 47 citations in OpenAlex.
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
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- Cognitive Maps in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment.iScience · 2025Article
- Context-invariant socioemotional encoding by prefrontal ensembles.Nature communications · 2025Article
- Differences and similarities between human hippocampal low-frequency oscillations during navigation and mental simulation.bioRxiv : the preprint server for biology · 2024Article
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
- Border cells without theta rhythmicity in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Context memory formed in medial prefrontal cortex during infancy enhances learning in adulthood.Nature communications · 2024Article
- A persistent prefrontal reference frame across time and task rules.Nature communications · 2024Article
- The novel estrogen receptor beta agonist EGX358 andFrontiers in aging neuroscience · 2024Article
- Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex.Nature communications · 2023Article
- Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.Cell reports · 2023Article
- Parallel Pathways Provide Hippocampal Spatial Information to Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Making Sense of the Multiplicity and Dynamics of Navigational Codes in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- No single place for space: neuronal representation of location beyond the hippocampus : Comment on: Sauer JF, Folschweiller S, Bartos M (2022) Topographically organized representation of space and context in the medial prefrontal cortex. PNAS 119:e2117300119.Pflugers Archiv : European journal of physiology · 2022Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Spatial tuning of neocortical pyramidal cells has been observed in diverse cortical regions and is thought to rely primarily on input from the hippocampal formation. Despite the well-studied hippocampal place code, many properties of the neocortical spatial tuning system are still insufficiently understood. In particular, it has remained unclear how the topography of direct anatomical connections from hippocampus to neocortex affects spatial tuning depth, and whether the dynamics of spatial coding in the hippocampal output region CA1, such as remapping in novel environments, is transmitted to the neocortex. Using mice navigating through virtual environments, we addressed these questions in the mouse medial prefrontal cortex, which receives direct input from the hippocampus. We found a rapidly emerging prefrontal representation of space in the absence of task rules, which discriminates familiar from novel environments and is reinstated upon reexposure to the same familiar environment. Topographical analysis revealed a dorsoventral gradient in the representation of the own position, which runs opposite to the innervation density of hippocampal inputs. Jointly, these results reveal a dynamically emerging and topographically organized prefrontal place code during spontaneous locomotion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.