Evidence map›Paper›PMID 35121661›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Cryo-ET of

Stella Y Sun, Li-Av Segev-Zarko, Muyuan Chen, Grigore D Pintilie, Michael F Schmid, Steven J Ludtke, John C Boothroyd, Wah Chiu

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Organization of Myosin H in the Apical Complex ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Apicortin defines theLife science alliance · 2026
    Article
  6. Review
  7. Cryogenic electron tomography by the numbers: Charting underexplored lineages in structural cell biology.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Two anchoring proteins control daughter apical complex assembly inbioRxiv : the preprint server for biology · 2026
    Article
  9. Microtubule inner proteins in apicomplexan parasites.Biochemical Society transactions · 2026
    Review
  10. Article
  11. The essential function of the apical polar ring during the blood stage ofbioRxiv : the preprint server for biology · 2026
    Article
  12. Atomic models of the Toxoplasma cell invasion machinery.Nature structural & molecular biology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Transfection of the free-living algabioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Stella Y SunDepartment of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305.ORCID 0000-0001-9004-8494
Li-Av Segev-ZarkoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-4151-5513
Muyuan ChenVerna Marrs and McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.
Grigore D PintilieDepartment of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305.
Michael F SchmidDivision of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.ORCID 0000-0003-1077-5750
Steven J LudtkeVerna Marrs and McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1903-1574
John C BoothroydDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305; jboothr@stanford.edu wahc@stanford.edu.
Wah ChiuDepartment of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305; jboothr@stanford.edu wahc@stanford.edu.ORCID 0000-0002-8910-3078
Clark University · USBaylor College of Medicine · USStanford University · USSLAC National Accelerator Laboratory · US

Funding

3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1M
Unified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6M
Acquisition of a 300 kV Electron Microscope for Structural BiologyS10OD021600 · OD · STANFORD UNIVERSITY · PI CHIU, WAH · 2016 to 2016
$2.0M
Tools for Quantitative Analysis of Complex Systems in CryoETP01GM121203 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI VOLKMANN, NIELS · 2018 to 2019
$1.9M
Determining structure and organization of neurofilaments in situ using cryo-electron tomographyR21MH125285 · NIMH · STANFORD UNIVERSITY · PI CHEN, MUYUAN · 2021 to 2022
$425k
NIGMS NIH HHS P01 GM121203NIGMS NIH HHS P41 GM103832NIGMS NIH HHS R01 GM079429NIH HHS S10 OD021600NIMH NIH HHS R21 MH125285
6 · The paper itself

Abstract

Tubulin is a conserved protein that polymerizes into different forms of filamentous structures in

Indexed as

AnimalsCytoskeletonElectron Microscope TomographyMicrotubule-Associated ProteinsMicrotubulesOrganellesParasitesProtozoan ProteinsToxoplasmaTubulinMicrotubule-Associated ProteinsProtozoan ProteinsTubulincryo-electron tomographycytoskeletonsubtomogram averagingToxoplasma gondiitubulin

Identifiers

PMID35121661
PMCPMC8832990
OpenAlexW4210247389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.