Evidence map›Paper›PMID 35121660›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.

Ian G Chambers, Praveen Kumar, Jens Lichtenberg, Pengcheng Wang, Jianshi Yu, John D Phillips, Maureen A Kane, David Bodine, Iqbal Hamza

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. An Emerging Paradigm for ABCC5/MRP5 Function in Human Physiology.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy.Liver international : official journal of the International Association for the Study of the Liver · 2024
    Review
  11. Article
  12. Review
  13. Drug Transporters at the Human Blood-Testis Barrier.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Review
  14. Review
  15. Molecular Mechanisms of Iron and Heme Metabolism.Annual review of nutrition · 2022
    Review
  16. Article
  17. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ian G ChambersDepartment of Animal and Avian Sciences and Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.
Praveen KumarDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.
Jens LichtenbergGenetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20814.ORCID 0000-0002-0023-4937
Pengcheng WangDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.ORCID 0000-0001-9626-6978
Jianshi YuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.ORCID 0000-0002-4666-2435
John D PhillipsDepartment of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132.
Maureen A KaneDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201.
David BodineGenetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20814.
Iqbal HamzaDepartment of Animal and Avian Sciences and Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742; hamza@umd.edu.ORCID 0000-0003-0045-0610
University of Maryland, Baltimore · USNational Human Genome Research Institute · USUniversity of Maryland, College Park · USUniversity of Utah · US

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
The Transport of Nutritional Heme in Animal DevelopmentR01DK085035 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI HAMZA, IQBAL · 2010 to 2019
$3.6M
Heme trafficking and recycling in iron metabolismR01DK125740 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI HAMZA, IQBAL · 2020 to 2023
$1.9M
Molecular determinants of retinoid metabolism in embryonic tissuesR01HD077260 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI KANE, MAUREEN A, MOISE, ALEX RADU · 2014 to 2018
$1.6M
Zeiss LSM 880 Airyscan Fast Laser Scanning ConfocalS10OD025223 · OD · UNIV OF MARYLAND, COLLEGE PARK · PI BEAVEN, AMY · 2019 to 2019
$557k
NICHD NIH HHS R01 HD077260NIDDK NIH HHS R01 DK085035NIDDK NIH HHS R01 DK125740NIDDK NIH HHS U54 DK110858NIH HHS S10 OD025223
6 · The paper itself

Abstract

Multidrug Resistance Proteins (MRPs) are transporters that play critical roles in cancer even though the physiological substrates of these enigmatic transporters are poorly elucidated. In

Indexed as

AnimalsATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BBiological TransportCaenorhabditis elegansHemeMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, KnockoutMitochondriaModels, AnimalReproductionSpermatozoaAbcc12 protein, mouseAbcc5 protein, mouseATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BHemefertilityhememitochondriamultidrug resistance proteinsreproduction

Identifiers

PMID35121660
PMCPMC8832985
OpenAlexW4220907121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.