Evidence map›Paper›PMID 35121635›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

A Farnesyltransferase Inhibitor Restores Cognitive Deficits in

Hiroko Sugiura, Tadayuki Shimada, Keiko Moriya-Ito, Jun-Ichi Goto, Hiroki Fujiwara, Rie Ishii, Hiroshi Shitara, Choji Taya, Satoshi Fujii, Toshiyuki Kobayashi and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Distinct early development trajectories in Nf1Journal of neurodevelopmental disorders · 2025
    Article
  2. Article
  3. Article
  4. mTOR-Dependent Spine Dynamics in Autism.Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Hiroko SugiuraLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Tadayuki ShimadaLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.ORCID 0000-0001-7333-9847
Keiko Moriya-ItoLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Jun-Ichi GotoDepartment of Physiology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
Hiroki FujiwaraDepartment of Physiology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
Rie IshiiLaboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Hiroshi ShitaraLaboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Choji TayaLaboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Satoshi FujiiDepartment of Physiology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
Toshiyuki KobayashiDepartment of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Okio HinoDepartment of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Paul F WorleyDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Kanato YamagataLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan yamagata-kn@igakuken.or.jp.ORCID 0000-0001-6183-2511
Tokyo Metropolitan Institute of Medical Science · JPYamagata University · JPJuntendo University · JPJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is caused by mutations in

Indexed as

Drug Resistant EpilepsyIntellectual DisabilityTuberous SclerosisAnimalsCognitionFarnesyltranstransferaseHumansMaleMechanistic Target of Rapamycin Complex 1MiceFarnesyltranstransferaseMechanistic Target of Rapamycin Complex 1FTImemoryneural activityspine morphologysynaptic plasticityTSC

Identifiers

PMID35121635
PMCPMC8944237
OpenAlexW4210374235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.