ArticleAJNR. American journal of neuroradiology2022
Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events.
Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Cracking the Code of Calcification: How Presence and Burden among Intracranial Arteries Influence Stroke Incidence and Recurrence.AJNR. American journal of neuroradiology · 2025Pooled it
- Hypointensity on Carotid Plaque MRI and Its Relationship to Calcification: Histopathologic Validation With Quantitative Susceptibility Mapping.Journal of magnetic resonance imaging : JMRI · 2026Article
- Territorial heterogeneity of atherosclerosis and vascular calcification.Nature cardiovascular research · 2026Review
- Computed Tomography Angiography "Rim Sign" for Detecting Carotid Intraplaque Hemorrhage: A Computed Tomography Angiography-Magnetic Resonance Imaging-Histology Correlation Study.Journal of the American Heart Association · 2026Article
- Geometric and density relationships of calcification clusters in carotid atherosclerosis.The neuroradiology journal · 2026Article
- Study on the correlation between carotid plaque calcification types and the recurrence of ischemic stroke.BMC medical imaging · 2026Article
- Area detection improves the person-based performance of a deep learning system for classifying the presence of carotid artery calcifications on panoramic radiographs.Oral radiology · 2026Article
- Calcified nodules in the cervical carotid artery.Surgical neurology international · 2026Article
- Association between carotid atherosclerotic plaque characteristics and white matter hyperintensity in cerebral small vessel disease.Frontiers in neurology · 2025Article
- Association between carotid plaque calcification and clinical outcomes of symptomatic cerebral small vessel disease.Frontiers in neurology · 2025Article
- Study on the correlation between carotid plaque calcification types and acute ischemic stroke.Frontiers in neurology · 2025Article
- Interlinking pathways: a narrative review on the role of IL-6 in cancer and atherosclerosis.Cardiovascular diagnosis and therapy · 2024Review
- Super Learner Algorithm for Carotid Artery Disease Diagnosis: A Machine Learning Approach Leveraging Craniocervical CT Angiography.Tomography (Ann Arbor, Mich.) · 2024Article
- Carotid artery calcium score: Definition, classification, application, and limits.The neuroradiology journal · 2024Article
- Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters.Heliyon · 2024Article
- Photon-Counting Computed Tomography Angiography of Carotid Arteries: A Topical Narrative Review with Case Examples.Diagnostics (Basel, Switzerland) · 2024Review
- Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study.BMC neurology · 2024Article
- Machine learning detects symptomatic patients with carotid plaques based on 6-type calcium configuration classification on CT angiography.European radiology · 2024Article
- Machine Learning Detects Symptomatic Plaques in Patients With Carotid Atherosclerosis on CT Angiography.Circulation. Cardiovascular imaging · 2024Article
- Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC.European heart journal · 2024Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCT is considered the standard reference both for quantification and characterization of carotid artery calcifications. Our aim was to investigate the relationship among different types of calcium configurations detected with CT within the plaque with a novel classification and to investigate the prevalence of cerebrovascular events. MATERIALS AND
methodsSeven hundred ninety patients (men = 332; mean age, 69.7 [SD, 13] years; 508 symptomatic for cerebrovascular symptoms and 282 asymptomatic) who underwent computed tomography of the carotid arteries were retrospectively included in this institutional review board-approved study. The plaque was classified into 6 types according to the different types of calcium configurations as the following: type 1, complete absence of calcification within the plaque; type 2, intimal or superficial calcifications; type 3, deep or bulky calcifications; type 4, adventitial calcifications with internal soft plaque of <2 mm thickness; type 5, mixed patterns with intimal and bulky calcifications; and type 6, positive rim sign.
resultsThe highest prevalence of cerebrovascular events was observed for type 6, for which 89 of the 99 cases were symptomatic. Type 6 plaque had the highest degree of correlation with TIA, stroke, symptoms, and ipsilateral infarct for both sides with a higher prevalence in younger patients. The frequency of symptoms observed by configuration type significantly differed between right and left plaques, with symptoms observed more frequently in type 6 calcification on the right side (50/53; 94%) than on the left side (39/46; 85%,
conclusionsWe propose a novel carotid artery plaque configuration classification that is associated with the prevalence of cerebrovascular events. If confirmed in longitudinal analysis, this classification could be used to stratify the risk of occurrence of ischemic events.
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