Evidence map›Paper›PMID 35121587›Full record

ArticleAJNR. American journal of neuroradiology2022

Proximal Region of Carotid Atherosclerotic Plaque Shows More Intraplaque Hemorrhage: The Plaque at Risk Study.

G A J C Crombag, M Aizaz, F H B M Schreuder, F Benali, D H K van Dam-Nolen, M I Liem, C Lucci, A F van der Steen, M J A P Daemen, W H Mess and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

G A J C CrombagFrom the Departments of Radiology and Nuclear Medicine (G.A.J.C.C., M.A., F.B., P.A.M.H., J.E.W., M.E.K.).ORCID 0000-0002-6233-3391
M AizazFrom the Departments of Radiology and Nuclear Medicine (G.A.J.C.C., M.A., F.B., P.A.M.H., J.E.W., M.E.K.).ORCID 0000-0002-9078-8924
F H B M SchreuderDepartment of Neurology & Donders Institute for Brain Cognition & Behaviour (F.H.B.M.S.), Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-7815-0207
F BenaliFrom the Departments of Radiology and Nuclear Medicine (G.A.J.C.C., M.A., F.B., P.A.M.H., J.E.W., M.E.K.).ORCID 0000-0002-1043-1125
D H K van Dam-NolenDepartments of Radiology and Nuclear Medicine (D.H.K.v.D.-N., A.v.d.L.).ORCID 0000-0002-4527-3876
M I LiemDepartments of Neurology (M.I.L., P.J.N.).ORCID 0000-0002-1353-8577
C LucciDepartment of Radiology (C.L., J.H.), University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-7427-2258
A F van der SteenBiomedical Engineering (A.F.v.d.S.), Erasmus University Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-8045-7363
M J A P DaemenPathology (M.J.A.P.D.), Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-1076-199X
W H MessClinical Neurophysiology (W.H.M.).ORCID 0000-0002-9736-9941
A van der LugtDepartments of Radiology and Nuclear Medicine (D.H.K.v.D.-N., A.v.d.L.).ORCID 0000-0002-6159-2228
P J NederkoornDepartments of Neurology (M.I.L., P.J.N.).ORCID 0000-0001-7386-4545
J HendrikseDepartment of Radiology (C.L., J.H.), University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0001-6384-6140
P A M HofmanFrom the Departments of Radiology and Nuclear Medicine (G.A.J.C.C., M.A., F.B., P.A.M.H., J.E.W., M.E.K.).ORCID 0000-0003-0961-4300
R J van OostenbruggeCARIM School for Cardiovascular Diseases (G.A.J.C.C., M.A., R.J.v.O., J.E.W., M.E.K.), Maastricht University, Maastricht, the Netherlands.ORCID 0000-0003-1032-9099
J E WildbergerFrom the Departments of Radiology and Nuclear Medicine (G.A.J.C.C., M.A., F.B., P.A.M.H., J.E.W., M.E.K.).ORCID 0000-0002-4810-6854
M E KooiFrom the Departments of Radiology and Nuclear Medicine (G.A.J.C.C., M.A., F.B., P.A.M.H., J.E.W., M.E.K.) eline.kooi@mumc.nl.ORCID 0000-0001-7562-5724
MACOM (United States) · USAnna Needs Neuroblastoma Answers · USHealth Services Research & Development · USUniversity Medical Center Utrecht · NLAmsterdam University Medical Centers · NLErasmus MC · NLInstitut de Neurophysiopathologie · FRMaastricht University · NLMaastricht University Medical Centre · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIntraplaque hemorrhage contributes to lipid core enlargement and plaque progression, leading to plaque destabilization and stroke. The mechanisms that contribute to the development of intraplaque hemorrhage are not completely understood. A higher incidence of intraplaque hemorrhage and thin/ruptured fibrous cap (upstream of the maximum stenosis in patients with severe [≥70%] carotid stenosis) has been reported. We aimed to noninvasively study the distribution of intraplaque hemorrhage and a thin/ruptured fibrous cap in patients with mild-to-moderate carotid stenosis. MATERIALS AND

methodsEighty-eight symptomatic patients with stroke (<70% carotid stenosis included in the Plaque at Risk study) demonstrated intraplaque hemorrhage on MR imaging in the carotid artery plaque ipsilateral to the side of TIA/stroke. The intraplaque hemorrhage area percentage was calculated. A thin/ruptured fibrous cap was scored by comparing pre- and postcontrast black-blood TSE images. Differences in mean intraplaque hemorrhage percentages between the proximal and distal regions were compared using a paired-samples

resultsWe found significantly larger areas of intraplaque hemorrhage in the proximal part of the plaque at 2, 4, and 6 mm from the maximal luminal narrowing, respectively: 14.4% versus 9.6% (

conclusionsWe demonstrated that intraplaque hemorrhage and a thin/ruptured fibrous cap are more prevalent on the proximal side of the plaque compared with the distal side in patients with mild-to-moderate carotid stenosis.

Indexed as

Carotid StenosisPlaque, AtheroscleroticStrokeCarotid ArteriesHemorrhageHumansMagnetic Resonance Imaging

Identifiers

PMID35121587
PMCPMC8985675
OpenAlexW4210279965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.