Evidence map›Paper›PMID 35121487›Full record

ArticleGait & posture2022

Overground versus treadmill walking in Parkinson's disease: Relationship between speed and spatiotemporal gait metrics.

Chiahao Lu, Kenneth H Louie, Emily L Twedell, Jerrold L Vitek, Colum D MacKinnon, Scott E Cooper

Open access · greenAbstract read
In one paragraph

Article in Gait & posture, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Parkinsonian gait improvement through vibratory stride parameter feedback.Journal of neuroengineering and rehabilitation · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Gait patterns during overground and virtual omnidirectional treadmill walking.Journal of neuroengineering and rehabilitation · 2024
    Article
  8. Gait Variability at Different Walking Speeds.Journal of functional morphology and kinesiology · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chiahao LuDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, United States. Electronic address: luxxx214@umn.edu.
Kenneth H LouieDepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, United States; Department of Neurological Surgery, University of California, 521 Parnassus Ave, M779, San Francisco, CA 94143, United States.
Emily L TwedellDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, United States; Department of Neuroscience, University of California, 495 Nelson Rising Lane, San Francisco, CA 94158, United States.
Jerrold L VitekDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, United States.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, United States.
Scott E CooperDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, United States.
University of Minnesota · USUniversity of Minnesota, Waseca · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI)UL1RR033183 · NCRR · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2011 to 2011
$8.9M
Predictors of progression to freezing of gait in Parkinson's diseaseR01NS088679 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2015 to 2018
$1.6M
NCATS NIH HHS UL1 TR000114NCRR NIH HHS UL1 RR033183NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS088679
6 · The paper itself

Abstract

backgroundTreadmills provide a safe and convenient way to study the gait of people with Parkinson's disease (PD), but outcome measures derived from treadmill gait may differ from overground walking.

objectiveTo investigate how the relationships between gait metrics and walking speed vary between overground and treadmill walking in people with PD and healthy controls.

methodsWe compared 29 healthy controls to 27 people with PD in the OFF-medication state. Subjects first walked overground on an instrumented gait walkway, then on an instrumented treadmill at 85%, 100% and 115% of their overground walking speed. Average stride length and cadence were computed for each subject in both overground and treadmill walking.

resultsStride length and cadence both differed between overground and treadmill walking. Regressions of stride length and cadence on gait speed showed a log-log relationship for both overground and treadmill gait in both PD and control groups. The difference between the PD and control groups during overground gait was maintained for treadmill gait, not only when treadmill speed matched overground speed, but also with ± 15% variation in treadmill speed from that value. SIGNIFICANCE: These results show that the impact of PD on stride length and cadence and their relationship to gait speed is preserved in treadmill as compared to overground walking. We conclude that a treadmill protocol is suitable for laboratory use in studies of PD gait therapeutics.

Indexed as

Parkinson DiseaseExercise TestGaitHumansWalkingWalking SpeedGait disordersOvergroundParkinson’s diseaseSpeedTreadmill

Identifiers

PMID35121487
PMCPMC8930449
OpenAlexW4210601529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.