ArticleRedox biology2022
Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation.
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Article in Redox biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Nitration in cancer signaling.Redox biology · 2026Review
- P2 X 7 receptor deficiency ameliorates high-fat-induced cardiac remodeling by improving oxidative stress through PI3K/AKT/GSK3β-mediated regulation of Nrf2.Journal of bioenergetics and biomembranes · 2026Article
- Toward Specific Detection of Peroxynitrite─Intramolecular Cyclization of Boronobenzylated Pyridinium Probe in Chemical and Cellular Systems.Chemical research in toxicology · 2026Article
- P2X7 receptor: a potential therapeutic target for chronic respiratory diseases.Molecular and cellular biochemistry · 2026Review
- Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M.Inflammation · 2025Article
- Recent advances in the investigation of the regulatory network underlying reactive nitrogen species-mediated tumorigenesis: molecular mechanisms and targeted therapeutic strategies.Redox report : communications in free radical research · 2025Review
- Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound.ACS omega · 2025Article
- Nitration-driven structural changes in Hsp90 linked to gain of pathological functions.The Biochemical journal · 2025Article
- Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer.Cancer research · 2025Article
- Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis.Biological trace element research · 2024Review
- Article
- Protein Tyrosine Amination: Detection, Imaging, and Chemoproteomic Profiling with Synthetic Probes.Journal of the American Chemical Society · 2024Article
- Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection.Antioxidants (Basel, Switzerland) · 2024Review
- Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases.Frontiers in immunology · 2024Review
- Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders.Frontiers in pharmacology · 2024Review
- Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite.Redox biology · 2023Article
- Interplay of carbon dioxide and peroxide metabolism in mammalian cells.The Journal of biological chemistry · 2022Review
- Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Megan JandyBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Asra NoorDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Pascal NelsonBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Cassandra N DennysBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Isabella M KarabinasDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Jeanine C PestoniDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Gautam D SinghDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Lam LucDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Rachel DevyldereDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Nathalie PerdomoBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Catherine E MitchellBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Levi AdamsBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Marisa A FuseRollins College, Winter Park, FL, 32789, USA.
Francine A MendozaDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Carrie L Marean-ReardonDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Ryan A MehlDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Alvaro G EstevezDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
Maria Clara FrancoDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA. Electronic address: maria.franco@oregonstate.edu.
Oregon State University · USUniversity of Central Florida · USRollins College · US
Funding
Equipment supplement: Defining Roles Of NitroTyrosine In Disease Via Genetic Code ExpansionR01GM114653 · NIGMS · OREGON STATE UNIVERSITY · PI MEHL, RYAN A · 2015 to 2024
$2.6MRedox Signaling in NeurofibromatosisR01NS102479 · NINDS · OREGON STATE UNIVERSITY · PI FRANCO, MARIA CLARA · 2019 to 2023
$1.7MDevelopment of an improved core technology for efficient genetic code expansion in biomedical researchR01GM131168 · NIGMS · OREGON STATE UNIVERSITY · PI MEHL, RYAN A · 2019 to 2021
$1.1MNIGMS NIH HHS R01 GM114653NIGMS NIH HHS R01 GM131168NINDS NIH HHS R01 NS102479
Abstract
The diffusion-limited reaction of nitric oxide (NO) and superoxide (O
Indexed as
Peroxynitrous AcidTyrosineAnimalsCell DeathHSP90 Heat-Shock ProteinsPC12 CellsPhosphatidylinositol 3-KinasesPTEN PhosphohydrolaseRatsReceptors, Purinergic P2X7HSP90 Heat-Shock ProteinsPeroxynitrous AcidPhosphatidylinositol 3-KinasesPTEN PhosphohydrolasePten protein, ratReceptors, Purinergic P2X7TyrosineApoptosisHsp90NitrotyrosineP2X7 receptorPeroxynitrite
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.