ArticleNeuroImage2022
Gaining insight into the neural basis of resting-state fMRI signal.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Enhanced hippocampal-cortical functional connectivity following post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI.Neuroscience bulletin · 2026Article
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- Quadrato Motor Training in Parkinson's Disease: Resting-State fMRI Changes and Exploratory Whole-Brain Radiomics.Bioengineering (Basel, Switzerland) · 2026Article
- Cortical hierarchy underlying homeostatic sleep pressure alleviation.Nature communications · 2025Article
- Computational mechanisms of neuroimaging biomarkers uncovered by multicenter resting-state fMRI connectivity variation profile.Molecular psychiatry · 2025Article
- Robust photogrammetric scalp morphology estimation for functional optical neuroimaging.Neurophotonics · 2025Article
- Sex-specific signatures of GLP-1 and amylin on resting state brain activity and functional connectivity in awake rats.Neuropharmacology · 2025Article
- Review
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.Nature communications · 2024Article
- Comparing structure-function relationships in brain networks using EEG and fNIRS.Scientific reports · 2024Article
- Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals.eLife · 2024Article
- Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals.Research square · 2024Article
- Article
- Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization.Nature communications · 2024Article
- Perturbing cortical networks:Frontiers in neuroscience · 2024Article
- Mapping and comparing fMRI connectivity networks across species.Communications biology · 2023Review
- Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden.Molecular psychiatry · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The blood oxygenation level-dependent (BOLD)-based resting-state functional magnetic resonance imaging (rsfMRI) has been widely used as a non-invasive tool to map brain-wide connectivity architecture. However, the neural basis underpinning the resting-state BOLD signal remains elusive. In this study, we combined simultaneous calcium-based fiber photometry with rsfMRI in awake animals to examine the relationship of the BOLD signal and spiking activity at the resting state. We observed robust couplings between calcium and BOLD signals in the dorsal hippocampus as well as other distributed areas in the default mode network (DMN), suggesting that the calcium measurement can reliably predict the rsfMRI signal. In addition, using the calcium signal recorded as the ground truth, we assessed the impacts of different rsfMRI data preprocessing pipelines on functional connectivity mapping. Overall, our results provide important evidence suggesting that spiking activity measured by the calcium signal plays a key role in the neural mechanism of resting-state BOLD signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.