Evidence map›Paper›PMID 35121007›Full record

ArticleJournal of insect physiology

Bloodmeal regulation in mosquitoes curtails dehydration-induced mortality, altering vectorial capacity.

Christopher J Holmes, Elliott S Brown, Dhriti Sharma, Quynh Nguyen, Austin A Spangler, Atit Pathak, Blaine Payton, Matthew Warden, Ashay J Shah, Samantha Shaw and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of insect physiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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  10. TargetingViruses · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christopher J HolmesDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States. Electronic address: holmescp@mail.uc.edu.
Elliott S BrownDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Dhriti SharmaDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Quynh NguyenDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Austin A SpanglerDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Atit PathakDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Blaine PaytonDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Matthew WardenDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Ashay J ShahDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Samantha ShawDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States.
University of Cincinnati · US

Funding

Mosquito hydration status as a mechanism that alters pre-feeding host interactions and post-feeding physiologyR01AI148551 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., XIAO, YANYU · 2020 to 2024
$2.1M
NIAID NIH HHS R01 AI148551
6 · The paper itself

Abstract

Mosquitoes readily lose water when exposed to any humidity less than that of near saturated air unless mitigated, leading to shifts in behavior, survival, distribution, and reproduction. In this study, we conducted a series of physiological experiments on two prominent species in the Culicinae subfamily: Culex pipiens, a vector of West Nile virus, and Aedes aegypti, a vector of yellow fever and Zika to examine the effects of dehydration. We exposed C. pipiens and A. aegypti to non-dehydrating conditions (saturated air), dehydrating conditions (air at a 0.89 kPa saturation vapor pressure deficit), several recovery conditions, as well as to bloodfeeding opportunities. We show that dehydrated mosquitoes increase bloodfeeding propensity, improve retention, and decrease excretion of a post-dehydration bloodmeal. In addition, mosquitoes that take a bloodmeal prior to dehydration exposure show increased survival over non-bloodfed counterparts. Dehydration-induced alterations in survival, reproduction, and bloodfeeding propensity of C. pipiens and A. aegypti resulted in marked changes to vectorial capacity. Ultimately, these results become increasingly important as drought intensifies in association with climate change and mosquitoes become more likely to experience arid periods.

Indexed as

AedesCulexWest Nile virusZika VirusZika Virus InfectionAnimalsDehydrationMosquito VectorsAedes aegyptiBloodfeedingCulex pipiensReproductionSurvivalVectorial capacity

Identifiers

PMID35121007
PMCPMC8885900
OpenAlexW4210450773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.