SynthesisThe Journal of pediatrics2022
Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis.
Synthesis in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Hypertension in middle childhood.BMC pediatrics · 2026Article
- Prevalence and clinical characteristics of secondary hypertension in young hypertensive tertiary care patients.Journal of human hypertension · 2026Article
- Relationship between lifestyle habits and blood pressure in Japanese high school students: a student-driven exploratory survey.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Observational
- Coiling in Renovascular Hypertension: A Case Report of Fibromuscular Dysplasia and Complex Urinary Tract Abnormalities.The American journal of case reports · 2025Article
- Oxidative Stress and Endothelial Dysfunction: The Pathogenesis of Pediatric Hypertension.International journal of molecular sciences · 2025Review
- Approach to pediatric renovascular hypertension.Childhood kidney diseases · 2025Review
- Secondary Hypertension in Children-Identifying and Investigating at Risk Children.Current hypertension reports · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Measurement of Blood Pressure in Children and Adolescents Outside the Office for the Diagnosis of Hypertension.Current cardiology reports · 2025Review
- Reliability of remote at-home oscillometric blood pressure monitoring in community-dwelling children aged 3-17.Frontiers in pediatrics · 2025Article
- Is Family History for the Management of Cardiovascular Health in Youth Still Relevant in Clinical Practice?Current atherosclerosis reports · 2024Review
- Screening and Management of Pediatric High Blood Pressure-Challenges to Implementing the Clinical Practice Guideline.Current hypertension reports · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Temporal Trends in Practice Patterns After Introduction of Pediatric Hypertension Guidelines in Canada.JAMA network open · 2024Article
- Diagnostic evaluation of the hypertensive child.Pediatric nephrology (Berlin, Germany) · 2024Article
- Factors Associated with Antihypertensive Therapy Prescription in Youth Delaware Medicaid Recipients with Primary Hypertension Diagnosis.American journal of hypertension · 2024Article
- Association of Area Deprivation With Primary Hypertension Diagnosis Among Youth Medicaid Recipients in Delaware.JAMA network open · 2023Article
- Approach to Diagnosis and Management of Pediatric Hypertension in an Outpatient Setting.Indian journal of nephrologyReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate the prevalence of secondary hypertension among otherwise healthy children with hypertension diagnosed in the outpatient setting. STUDY
designThe MEDLINE, PubMed Central, Embase, Web of Science, and Cochrane Library databases were systematically searched for observational studies reporting the prevalence of secondary hypertension in children who underwent evaluation for hypertension and had no known comorbidities associated with hypertension at the time of diagnosis. Two authors independently extracted the study-specific prevalence of secondary hypertension in children evaluated for hypertension. Prevalence estimates for secondary hypertension were pooled in a random-effects meta-analysis.
resultsNineteen prospective studies and 7 retrospective studies including 2575 children with hypertension were analyzed, with a median of 65 participants (range, 9-486) in each study. Studies conducted in primary care or school settings reported a lower prevalence of secondary hypertension (3.7%; 95% CI, 1.2%-7.2%) compared with studies conducted in referral clinics (20.1%; 95% CI, 11.5%-30.3%). When stratified by study setting, there were no significant subgroup differences according to study design, country, participant age range, hypertension definition, blood pressure device, or study quality. Although the studies applied different approaches to diagnosing secondary hypertension, diagnostic evaluations were at least as involved as the limited testing recommended by current guidelines.
conclusionsThe low prevalence of secondary hypertension among children with a new diagnosis of hypertension identified on screening reinforces clinical practice guidelines to avoid extensive testing in the primary care setting for secondary causes in most children with hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.