Evidence map›Paper›PMID 35120596›Full record

ArticleStructure (London, England : 1993)2022

Tsg101/ESCRT-I recruitment regulated by the dual binding modes of K63-linked diubiquitin.

Madeleine Strickland, Susan Watanabe, Steven M Bonn, Christina M Camara, Mary R Starich, David Fushman, Carol A Carter, Nico Tjandra

Open access · greenAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. ESCRTing the RABs through conversion.Biochemical Society transactions · 2025
    Review
  8. Tsg101 mimicry of canonical E2 enzymes underlies its role in ubiquitin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Bioengineering extracellular vesicle cargo for optimal therapeutic efficiency.Molecular therapy. Methods & clinical development · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Madeleine StricklandBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Room 3503, Bethesda, MD 20892, USA.
Susan WatanabeDepartment of Microbiology & Immunology, Renaissance School of Medicine, Stony Brook University, Life Sciences Bldg. Room 248, Stony Brook, NY 11794-5222, USA.
Steven M BonnDepartment of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA.
Christina M CamaraDepartment of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA.
Mary R StarichBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Room 3503, Bethesda, MD 20892, USA.
David FushmanDepartment of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA.
Carol A CarterDepartment of Microbiology & Immunology, Renaissance School of Medicine, Stony Brook University, Life Sciences Bldg. Room 248, Stony Brook, NY 11794-5222, USA. Electronic address: carol.carter@stonybrook.edu.
Nico TjandraBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Room 3503, Bethesda, MD 20892, USA. Electronic address: tjandran@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USUniversity of Maryland, College Park · USStony Brook School · US

Funding

Nmr Studies Of The Regulation Of Cell SignalingZIAHL001048 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI TJANDRA, NICO · 2009 to 2025
$20.1M
Solution structure and dynamics of polyubiquitin chainsR01GM065334 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DAVID FUSHMAN · 2002 to 2026
$6.2M
NMR STUDIES OF THE REGULATION OF CELL SIGNALINGZ01HL001048 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI TJANDRA, NICO · 1998 to 2008
$3.4M
Cellular Protein Involved in Trafficking of HIV-1R01AI150489 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI CARTER, CAROL A · 2020 to 2022
$1.2M
Intramural NIH HHS Z01 HL001048Intramural NIH HHS ZIA HL001048NIAID NIH HHS R01 AI150489NIGMS NIH HHS R01 GM065334
6 · The paper itself

Abstract

The ESCRT-I protein Tsg101 plays a critical role in viral budding and endocytic sorting. Although Tsg101 is known to recognize monoubiquitin (Ub

Indexed as

Binding SitesDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportHumansLanthanoid Series ElementsLysineMagnetic Resonance SpectroscopyModels, MolecularProtein ConformationProtein DomainsTranscription FactorsTsg101 ProteinUbiquitinDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportLanthanoid Series ElementsLysineTranscription FactorsTsg101 ProteinUbiquitinCPMGdiubiquitinendocytic sortingESCRTHrsNMRTsg101viral budding

Identifiers

PMID35120596
PMCPMC10015442
OpenAlexW4220765897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.