Evidence map›Paper›PMID 35120418›Full record

ArticleInternational journal of immunopathology and pharmacology

The effect of valproic acid on SLC5A8 expression in gonad-intact and gonadectomized rat thymocytes.

Milda Juknevičienė, Ingrida Balnytė, Angelija Valančiūtė, Jūratė Stanevičiūtė, Kęstutis Sužiedėlis, Donatas Stakišaitis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Milda JuknevičienėDepartment of Histology and Embryology, Medical Academy, 230647Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ingrida BalnytėDepartment of Histology and Embryology, Medical Academy, 230647Lithuanian University of Health Sciences, Kaunas, Lithuania.
Angelija ValančiūtėDepartment of Histology and Embryology, Medical Academy, 230647Lithuanian University of Health Sciences, Kaunas, Lithuania.
Jūratė StanevičiūtėDepartment of Histology and Embryology, Medical Academy, 230647Lithuanian University of Health Sciences, Kaunas, Lithuania.
Kęstutis SužiedėlisLaboratory of Molecular Oncology, National Cancer Institute, Vilnius, Lithuania.
Donatas StakišaitisDepartment of Histology and Embryology, Medical Academy, 230647Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID https://orcid.org/0000-0002-1547-7050
Lithuanian University of Health Sciences · LTNational Cancer Institute · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundValproic acid (VPA) pharmacological mechanisms are related to the anti-inflammatory and anti-viral effects. VPA is a histone deacetylases inhibitor and serves a role in its immunomodulatory impacts. VPA has complex effects on immune cell's mitochondrial metabolism. The SLC5A8 transporter of short fatty acids has an active role in regulating mitochondrial metabolism. The study aimed to investigate whether SLC5A8 expresses the sex-related difference and how SLC5A8 expression depends on gonadal hormones, VPA treatment, and NKCC1 expression in rat thymocytes.

methodsControl groups and VPA-treated gonad-intact and gonadectomized Wistar male and female rats were investigated (

resultsThe higher

conclusionVPA effect on the

Indexed as

AnimalsAnticonvulsantsFemaleGene ExpressionMaleMonocarboxylic Acid TransportersOrchiectomyOvariectomyOvaryRatsRats, WistarSex CharacteristicsTestisThymocytesValproic AcidAnticonvulsantsMonocarboxylic Acid TransportersSLC5A8 protein, ratValproic Acidsex-related differenceSLC5A8thymocytevalproic acid

Identifiers

PMID35120418
PMCPMC8819739
OpenAlexW4210790213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.