ArticleMolecular nutrition & food research2022
Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes.
Article in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Effect of blueberry intervention on endothelial function: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Scientific Evidence for the Beneficial Effects of Dietary Blueberries on Gut Health: A Systematic Review.Molecular nutrition & food research · 2023Pooled it
- Wild blueberries and cardiometabolic health: a current review of the evidence.Critical reviews in food science and nutrition · 2026Review
- Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation.Gut microbes · 2025Article
- Dietary Prebiotics Modulate Omeprazole-Induced Alterations in the Gut Microbial Signature.Molecular nutrition & food research · 2025Article
- Exploring Individual Factors Affecting Endothelial Function Response Variability in Aging: Implications for Precision Nutrition.Nutrients · 2025Review
- The relationship between carotenoids and diabetic nephropathy: insights from NHANES.Frontiers in nutrition · 2025Article
- The state of the science on the health benefits of blueberries: a perspective.Frontiers in nutrition · 2024Article
- Protective effects of blueberries on vascular function: A narrative review of preclinical and clinical evidence.Nutrition research (New York, N.Y.) · 2023Review
- The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction.Cardiovascular diabetology · 2023Review
- Nox4 as a novel therapeutic target for diabetic vascular complications.Redox biology · 2023Review
- Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature.Antioxidants (Basel, Switzerland) · 2023Article
- Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro β-Cell Functions Critical for Metabolic Health.Metabolites · 2023Article
- Review
- Review
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N-oxide by modulating gut microbes.BioFactors (Oxford, England)Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
Abstract
scopeIn diabetes, endothelial inflammation and dysfunction play a pivotal role in the development of vascular disease. This study investigates the effect of dietary blueberries on vascular complications and gut microbiome in diabetic mice. METHODS AND
resultsSeven-week-old diabetic db/db mice consume a standard diet (db/db) or a diet supplemented with 3.8% freeze-dried blueberry (db/db+BB) for 10 weeks. Control db/+ mice are fed a standard diet (db/+). Vascular inflammation is assessed by measuring monocyte binding to vasculature and inflammatory markers. Isometric tension procedures are used to assess mesenteric artery function. db/db mice exhibit enhanced vascular inflammation and reduced endothelial-dependent vasorelaxation as compared to db/+ mice, but these are improved in db/db+BB mice. Blueberry supplementation reduces the expression of NOX4 and IκKβ in the aortic vessel and vascular endothelial cells (ECs) isolated from db/db+BB compared to db/db mice. The blueberry metabolites serum reduces glucose and palmitate induced endothelial inflammation in mouse aortic ECs. Further, blueberry supplementation increases commensal microbes and modulates the functional potential of gut microbes in diabetic mice.
conclusionDietary blueberry suppresses vascular inflammation, attenuates arterial endothelial dysfunction, and supports the growth of commensal microbes in diabetic mice. The endothelial-specific vascular benefits of blueberries are mediated through NOX4 signaling.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.