Evidence map›Paper›PMID 35119930›Full record

ArticleScience advances2022

Pore structure controls stability and molecular flux in engineered protein cages.

Lachlan S R Adamson, Nuren Tasneem, Michael P Andreas, William Close, Eric N Jenner, Taylor N Szyszka, Reginald Young, Li Chen Cheah, Alexander Norman, Hugo I MacDermott-Opeskin and 4 more

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Chemical reviews · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Encapsulins: catalysis inside a shell.Current opinion in microbiology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Structural Diversity of Encapsulin Protein Shells.Chembiochem : a European journal of chemical biology · 2024
    Review
  14. Structural Characterization ofMicroorganisms · 2024
    Article
  15. Article
  16. Article
  17. Encapsulation of Transketolase intoACS applied bio materials · 2024
    Article
  18. Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lachlan S R AdamsonSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-9862-9557
Nuren TasneemSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-1125-7149
Michael P AndreasDepartment of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-8871-3053
William CloseAustralian Centre for Microscopy and Microanalysis, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-1481-7068
Eric N JennerSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0003-2696-2534
Taylor N SzyszkaSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-9921-3086
Reginald YoungSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.
Li Chen CheahCSIRO Future Science Platform in Synthetic Biology, Commonwealth Scientific and Industrial Research Organisation (CSIRO), 41 Boggo Road, Dutton Park, QLD 4102, Australia.ORCID 0000-0002-0072-2885
Alexander NormanSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.
Hugo I MacDermott-OpeskinResearch School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia.ORCID 0000-0002-7393-7457
Megan L O'MaraResearch School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia.ORCID 0000-0002-8764-1585
Frank SainsburyCSIRO Future Science Platform in Synthetic Biology, Commonwealth Scientific and Industrial Research Organisation (CSIRO), 41 Boggo Road, Dutton Park, QLD 4102, Australia.ORCID 0000-0001-8152-3820
Tobias W GiessenDepartment of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-6328-2031
Yu Heng LauSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0001-6560-8410

Funding

Protein Organelles In Human-Associated BacteriaR35GM133325 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Tobias Wolfgang Giessen · 2019 to 2026
$3.8M
NIGMS NIH HHS R35 GM133325
6 · The paper itself

Abstract

Protein cages are a common architectural motif used by living organisms to compartmentalize and control biochemical reactions. While engineered protein cages have featured in the construction of nanoreactors and synthetic organelles, relatively little is known about the underlying molecular parameters that govern stability and flux through their pores. In this work, we systematically designed 24 variants of the

Identifiers

PMID35119930
PMCPMC8816334

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.