Evidence map›Paper›PMID 35119925›Full record

ArticleScience advances2022

P2X4 and P2X7 are essential players in basal T cell activity and Ca

Valerie J Brock, Insa M A Wolf, Marco Er-Lukowiak, Niels Lory, Tobias Stähler, Lena-Marie Woelk, Hans-Willi Mittrücker, Christa E Müller, Friedrich Koch-Nolte, Björn Rissiek and 3 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 50 citations in OpenAlex.

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  15. Review
  16. Metal Ion Signaling in Biomedicine.Chemical reviews · 2025
    Review
  17. Imaging BiTE-Mediated Activation of Primary Human CD8Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Valerie J BrockThe Ca2+ Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-5547-499X
Insa M A WolfThe Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Marco Er-LukowiakDepartment of Neurology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-9130-1818
Niels LoryDepartment of Immunology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-4735-4968
Tobias StählerDepartment of Immunology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-0845-3800
Lena-Marie WoelkDepartment of Computational Neuroscience, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.
Hans-Willi MittrückerDepartment of Immunology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-6166-4191
Christa E MüllerDepartment of Pharmacy, University of Bonn, 53121 Bonn, Germany.ORCID 0000-0002-0013-6624
Friedrich Koch-NolteDepartment of Immunology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-1730-6674
Björn RissiekDepartment of Neurology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-5327-5479
René WernerDepartment of Computational Neuroscience, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-2296-3305
Andreas H GuseThe Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-3972-401X
Björn-Philipp DiercksThe Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-6635-1706
Universität Hamburg · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Initial T cell activation is triggered by the formation of highly dynamic, spatiotemporally restricted Ca

Identifiers

PMID35119925
PMCPMC8816335
OpenAlexW4210292760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.