ArticleScience advances2022
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- De-extinction of the Northern white rhinoceros (Ceratotherium simum cottoni).The Journal of reproduction and development · 2026Review
- Cetacean loss of the master adipose tissue regulator βNature communications · 2025Article
- Evolutionary adaptations of TRPA1 thermosensitivity and skin thermoregulation in vertebrates.iScience · 2025Article
- Article
- The genome of African manateeiScience · 2024Article
- Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria.Nature communications · 2024Article
- A chromosome-level genome assembly for the dugong (Dugong dugon).The Journal of heredity · 2024Article
- From teeth to pad: tooth loss and development of keratinous structures in sirenians.Proceedings. Biological sciences · 2023Article
- Hybridization of Atlantic puffins in the Arctic coincides with 20th-century climate change.Science advances · 2023Article
- Article
- Steller's sea cow uncertain history illustrates importance of ecological context when interpreting demographic histories from genomes.Nature communications · 2022Article
Corrections and comments
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Authors and funding
22 authors at 15 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold aquatic (or marine) environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis, a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. We also found that Steller's sea cows' abundance was continuously declining for tens of thousands of years before their description, implying that environmental changes also contributed to their extinction.
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