Evidence map›Paper›PMID 35119910›Full record

ReviewAnnual review of immunology2022

Gene Regulatory Circuits in Innate and Adaptive Immune Cells.

Ankita Saini, Hazem E Ghoneim, Chan-Wang Jerry Lio, Patrick L Collins, Eugene M Oltz

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. [Role of Trained Immunity in the Association Between Periodontitis and Rheumatoid Arthritis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  6. The Role of MClinical reviews in allergy & immunology · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ankita SainiDepartment of Microbial Infection and Immunity and Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio, USA; email: patrick.collins@osumc.edu, eugene.oltz@osumc.edu.
Hazem E GhoneimDepartment of Microbial Infection and Immunity and Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio, USA; email: patrick.collins@osumc.edu, eugene.oltz@osumc.edu.
Chan-Wang Jerry LioDepartment of Microbial Infection and Immunity and Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio, USA; email: patrick.collins@osumc.edu, eugene.oltz@osumc.edu.
Patrick L CollinsDepartment of Microbial Infection and Immunity and Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio, USA; email: patrick.collins@osumc.edu, eugene.oltz@osumc.edu.
Eugene M OltzDepartment of Microbial Infection and Immunity and Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio, USA; email: patrick.collins@osumc.edu, eugene.oltz@osumc.edu.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

CIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8M
Topological Control of Antigen Receptor Loci during Lymphocyte DevelopmentR01AI130231 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSING, CRAIG H, OLTZ, EUGENE M · 2017 to 2021
$3.8M
TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTESR37AI118852 · NIAID · OHIO STATE UNIVERSITY · PI Eugene M Oltz · 2021 to 2026
$2.8M
TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTESR01AI118852 · NIAID · WASHINGTON UNIVERSITY · PI OLTZ, EUGENE M · 2015 to 2019
$1.9M
SEQUENCE-SPECIFIC CHROMATIN MODIFIERS; NOVEL PROTEIN THERAPEUTICS FOR B CELL LYMPHOMAR01CA188286 · NCI · WASHINGTON UNIVERSITY · PI OLTZ, EUGENE M, PAYTON, JACQUELINE E. · 2015 to 2019
$1.7M
TET-mediated Epigenetic Regulation in the Development and Immunoevasion of B cell LymphomaK22CA241290 · NCI · OHIO STATE UNIVERSITY · PI LIO, JERRY CHAN-WANG · 2020 to 2022
$485k
Gene regulatory architecture of CD56 bright natural killer cellsR21AI156411 · NIAID · OHIO STATE UNIVERSITY · PI COLLINS, PATRICK LEONARD · 2021 to 2022
$433k
NCI NIH HHS K22 CA241290NCI NIH HHS R01 CA188286NIAID NIH HHS R01 AI118852NIAID NIH HHS R01 AI130231NIAID NIH HHS R01 AI134035NIAID NIH HHS R21 AI156411NIAID NIH HHS R37 AI118852
6 · The paper itself

Abstract

Cell identity and function largely rely on the programming of transcriptomes during development and differentiation. Signature gene expression programs are orchestrated by regulatory circuits consisting of

Indexed as

ChromatinGene Regulatory NetworksAnimalsGene Expression RegulationHumansPromoter Regions, GeneticTranscription FactorsChromatinTranscription Factorsadaptive lymphoid cellschromatinepigeneticsgene regulationinnate lymphoid cellstranscription factors

Identifiers

PMID35119910
PMCPMC9241025
OpenAlexW4210322985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.