Evidence map›Paper›PMID 35119686›Full record

ArticleJournal of nephrology2022

Chikungunya virus as a trigger for different renal disorders: an exploratory study.

Denise Maria do Nascimento Costa, Carlos Eduardo Machado, Precil Diego Neves, Dyego José Brito, Samira Oi, Flávio Henrique Barros, Luiz Tadeu Figueiredo, Stanley Almeida Araujo, Francisco Ladchumananandasivam, Marlene Antônia Dos Reis and 13 more

Abstract read
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In one paragraph

Article in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Extra-articular Manifestations of Chikungunya.Revista da Sociedade Brasileira de Medicina Tropical · 2023
    Review
  5. The research progress of Chikungunya fever.Frontiers in public health · 2022
    Review
  6. Common arboviruses and the kidney: a review.Jornal brasileiro de nefrologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 1 country.

Denise Maria do Nascimento CostaNephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil. denisecosta_81@yahoo.com.ORCID http://orcid.org/0000-0001-7306-7044
Carlos Eduardo MachadoUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Precil Diego NevesDivisions of Nephrology and Molecular Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Dyego José BritoUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Samira OiUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Flávio Henrique BarrosUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Luiz Tadeu FigueiredoVirology Department, Ribeirão , Preto Medical School of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Stanley Almeida AraujoMicroscopy Center of the Federal University of Minas Gerais and Institute of Nephropathology, Belo Horizonte, Minas Gerais, Brazil.
Francisco LadchumananandasivamUniversity Hospital of the Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Marlene Antônia Dos ReisFederal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Weverton LuchiFederal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Joyce LagesUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Natalino Salgado FilhoUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Luiz Fernando OnuchicDivisions of Nephrology and Molecular Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Angela Luzia DuarteRheumatology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Claudia Diniz Lopes MarquesRheumatology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Maria Rosângela Cunha Duarte CoêlhoVirology Division, Laboratory of Immunopathology Keizo Asami of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Camila OliveiraNephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Gisele VajgelNephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Maria Alina CavalcanteNephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Lucila ValenteNephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Vera MagalhãesDepartment of Tropical Medicine, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Gyl Eanes Barros SilvaUniversity Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Universidade Federal de Pernambuco · BRUniversidade Federal do Maranhão · BRUniversidade de São Paulo · BRUniversidade Federal da Paraíba · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal do Espírito Santo · BRUniversidade Federal do Triângulo Mineiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChikungunya virus was detected in cases of acute chikungunya fever in renal tissue. However, chikungunya virus-related kidney injury still lacks characterization, and it is unknown whether the kidneys are reservoirs for the virus. We sought to detect histopathological changes and viral antigens in renal tissue, and to evaluate kidney injury markers in different phases of chikungunya fever.

methodsTwo groups were evaluated in this exploratory study: patients with biopsy-proven kidney injury established after chikungunya fever, and patients with post-chikungunya fever chronic joint manifestations without known kidney injury, in whom we actively searched for kidney injury markers.

resultsIn the first group, 15 patients had kidney injury 0.5-24 months after chikungunya fever. The most frequent histopathological diagnoses were glomerular lesions. No viral antigens were detected in renal tissue. High-risk genotypes were detected in patients with atypical hemolytic uremic syndrome and focal and segmental glomerulosclerosis. In the second group, 114 patients had post-chikungunya fever joint manifestations on average for 35.6 months. Mean creatinine and proteinuria were 0.9 mg/dl and 71.5 mg/day, respectively. One patient had isolated hematuria. There was no indication for renal biopsy in this group.

conclusionsSeveral histopathological features were found after chikungunya fever, without virus detection in renal tissue. These findings suggest that chikungunya virus may trigger kidney lesions with varying degrees of severity at different stages of infection. However, the probability that this virus replicates in the renal tissue seems unlikely.

Indexed as

Chikungunya FeverChikungunya virusGlomerulosclerosis, Focal SegmentalKidney DiseasesHumansKidney GlomerulusChikungunya feverChikungunya virusGlomerulopathyKidney injury

Identifiers

PMID35119686
OpenAlexW4210318426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.