Evidence map›Paper›PMID 35119666›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Use of Reporter Genes to Analyze Estrogen Response: The Transgenic Zebrafish Model.

Daniel A Gorelick, Caroline Lucia, Ruixin Hao, Silvia Karim, Maria Bondesson

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel A GorelickCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Caroline LuciaDepartment of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA.
Ruixin HaoDepartment of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA.
Silvia KarimDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.
Maria BondessonDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA. mbondess@iu.edu.

Funding

Estrogen receptor activity in zebrafish mating behaviorsF32HD061119 · NICHD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI GORELICK, DANIEL · 2009 to 2011
$168k
NICHD NIH HHS F32 HD061119
6 · The paper itself

Abstract

In vivo models to detect estrogenic compounds are very valuable for screening for endocrine disruptors. Here we describe the use of transgenic estrogen reporter zebrafish as an in vivo model for the identification of estrogenic properties of compounds. Live imaging of these transgenic fish provides knowledge of estrogen receptor specificity of different ligands as well as dynamics of estrogen signaling. Coupled to image analysis, the model can provide quantitative concentration-response information on estrogenic activity of chemical compounds.

Indexed as

Endocrine DisruptorsZebrafishAnimalsAnimals, Genetically ModifiedEstrogensGenes, ReporterEndocrine DisruptorsEstrogensEstrogen receptorFluorescence microscopyImage analysisTransgenic zebrafishXenoestrogens

Identifiers

PMID35119666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.