Evidence map›Paper›PMID 35119623›Full record

ArticleAnnals of nuclear medicine2022

I-124 PET/CT image-based dosimetry in patients with differentiated thyroid cancer treated with I-131: correlation of patient-specific lesional dosimetry to treatment response.

Donika Plyku, Robert F Hobbs, Di Wu, Carlos Garcia, George Sgouros, Douglas Van Nostrand

Abstract read
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In one paragraph

Article in Annals of nuclear medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Guideline
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  3. Image quality and lesion detectability in simulated [European journal of nuclear medicine and molecular imaging · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Donika Plyku *Division, Nuclear Medicine Research, MedStar Health Research Institute, Hyattsville, MD, USA.ORCID http://orcid.org/0000-0001-7305-8834
Robert F Hobbs *Radiological Physics Division Department of Radiology and Radiological Sciences, Johns Hopkins University, School of Medicine, 1550 Orleans St., CRBII 4M.61, Baltimore, MD, 21231, USA.
Di WuDivision, Nuclear Medicine Research, MedStar Health Research Institute, Hyattsville, MD, USA.
Carlos GarciaDivision of Nuclear Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
George SgourosRadiological Physics Division Department of Radiology and Radiological Sciences, Johns Hopkins University, School of Medicine, 1550 Orleans St., CRBII 4M.61, Baltimore, MD, 21231, USA. gsgouros@gmail.com.
Douglas Van NostrandDivision, Nuclear Medicine Research, MedStar Health Research Institute, Hyattsville, MD, USA. douglas.van.nostrand@medstar.net.
MedStar Washington Hospital Center · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this study is to evaluate the lesion absorbed dose (AD), biological effective dose (BED), and equivalent uniform dose (EUD) to clinical-response relationship in lesional dosimetry for

methodsNineteen lesions in four patients with metastatic differentiated thyroid cancer (DTC) were evaluated. The patients underwent PET/CT imaging at 2 h, 24 h, 48 h, 72 h, and 96 h post administration of ~ 33-65 MBq (0.89-1.76 mCi) of

resultsThe lesion responses were CR and PR (58%, 11/19 lesions), SD (21%, 4/19), and PD (21%, 4/19). For CR and PR lesions, the ADs, BEDs and EUDs were > 75 Gy for 82% (9/11) and < 75 Gy for 18% (2/11). The ADs and BEDs were < 75 Gy for SD and PD lesions.

conclusionBy performing retrospective dosimetry calculations for

Indexed as

Iodine RadioisotopesThyroid NeoplasmsHumansPositron Emission Tomography Computed TomographyRadiometryRetrospective StudiesIodine-124Iodine-131Iodine RadioisotopesDifferentiated thyroid cancerDosimetryImagingRadionuclide therapyResponse

Identifiers

PMID35119623
OpenAlexW4210721730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.