Evidence map›Paper›PMID 35119557›Full record

ArticleEJNMMI research2022

Preclinical biodistribution and dosimetry and human biodistribution comparing

Karina Knorr, So Won Oh, Markus Krönke, Alexander Wurzer, Calogero D'Alessandria, Michael Herz, Wolfgang Weber, Hans-Jürgen Wester, Matthias Eiber, Nahid Yusufi and 1 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Biochemical failure-free survival ofScientific reports · 2025
    Article
  3. Article
  4. Article
  5. Preclinical comparison of [EJNMMI radiopharmacy and chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Karina KnorrSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany. karina.knorr@mri.tum.de.ORCID http://orcid.org/0000-0003-2022-4805
So Won OhSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Markus KrönkeSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Alexander WurzerChair for Pharmaceutical Radiopharmacy, TUM, Garching, Germany.
Calogero D'AlessandriaSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Michael HerzSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Wolfgang WeberSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Hans-Jürgen WesterChair for Pharmaceutical Radiopharmacy, TUM, Garching, Germany.
Matthias EiberSchool of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Nahid Yusufi *School of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Stephan Nekolla *School of Medicine, Klinikum Rechts der Isar, Department of Nuclear Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
TUM Klinikum · DETechnical University of Munich · DESeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiohybrid prostate-specific membrane antigen (rhPSMA) ligands such as

methodsPreclinical dosimetry was performed with SCID-mice sacrificed at multiple timepoints (10-300 min) post-injection of 25.6 ± 3.6 MBq

resultsPreclinical dosimetry revealed that at 3.5 h and 1 h bladder voiding intervals, the extrapolated total effective doses were 26.6 and 12.2 µSv/MBq for

conclusionsRadiation dosimetry is favourable for both agents. Radiation exposure, assuming a 1 h voiding interval, is less than 5 mSv after injection of 370 MBq.

Indexed as

18FBiodistributionDosimetryPET/CTPSMArhPSMA

Identifiers

PMID35119557
PMCPMC8816989
OpenAlexW4210299155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.