ArticleJournal of assisted reproduction and genetics2022
Preimplantation genetic testing for aneuploidy (PGT-A)-a single-center experience.
Article in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Misdiagnosis of different types of aneuploidy in preimplantation genetic testing (PGT): a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2026Pooled it
- Optimisation of Laser-Assisted Biopsy Parameters in Bovine Embryos.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Factors associated withFrontiers in endocrinology · 2026Article
- Classification of recurrent implantation failure patients using peripheral blood immunological and metabolic markers.BioImpacts : BI · 2026Article
- Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma.PLoS biology · 2026Article
- Outcomes of frozen embryo transfers from a large monocentric cohort (2982 cycles): towards a preferential use of cycles with aFrontiers in endocrinology · 2026Article
- Changes in sequencing technology used for preimplantation genetic testing for aneuploidy.Journal of assisted reproduction and genetics · 2025Review
- Incidence of aneuploidy in embryos studied using PGT-A in Mexico: a clinical retrospective experience.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Uniparental disomy (UPD) exclusion in embryos following Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR).Journal of assisted reproduction and genetics · 2025Article
- The correlation between morphological parameters and the incidence of de novo chromosomal abnormalities in 3238 biopsied blastocysts.Journal of assisted reproduction and genetics · 2023Article
- No crystal stair: supporting fertility care and the pursuit of pregnancy in women with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2022Article
- A Mini-Review Regarding the Clinical Outcomes of In Vitro Fertilization (IVF) Following Pre-Implantation Genetic Testing (PGT)-Next Generation Sequencing (NGS) Approach.Diagnostics (Basel, Switzerland) · 2022Review
- A successful case of preimplantation genetic testing for monogenic disorder for aplasia cutis congenita.Frontiers in pediatrics · 2022Article
- Controlled ovarian hyperstimulation parameters are not associated withFrontiers in endocrinology · 2022Article
- Patterns of Preimplantation Genetic Testing Utilization During In Vitro Fertilization in a Nigerian Fertility Centre: Sociodemographic Characteristics and Clinical Indications.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
- Clinical Use of Non-Invasive Preimplantation Genetic Testing - A Joint Position Statement from the Indian Society for Assisted Reproduction, Indian Fertility Society and Academy of Clinical Embryologists.Journal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to determine the prevalence and nature of human embryonic aneuploidy based on the preimplantation genetic testing for aneuploidy (PGT-A), the distribution of aneuploidy across the individual chromosomes, and their relationship to maternal age.
methodsThis is a retrospective cohort study conducted at a single center. The study includes subjects who opted for PGT-A in their in vitro fertilization (IVF) cycle from 2016 to 2020. PGT-A was performed on 1501 embryos from 488 patients in 535 cycles. PGT-A was performed using NGS-based technique on Ion Torrent PGM (Life Technologies). Analysis was performed to determine the (i) frequency of the aneuploidy, (ii) the chromosome most commonly affected, (iii) relationship between maternal age and the rate of aneuploidy, and (iv) incidence of segmental aneuploidy.
resultsThe overall frequency of aneuploidy was observed to be 46.8%. The incidence of aneuploidy rate was ~ 28% at maternal age < 30 years which steadily increased to ~ 67% in women above 40 years. High frequency of aneuploidy was observed in chromosomes 16, 22, 21, and 15. Segmental abnormalities, involving loss or gain of chromosomal fragments, were observed at a frequency of 5.3%, and highest incidence of segmental gain was observed on the q-arm of chromosome 9.
conclusionThe study provides important information regarding the frequency of the aneuploidy in IVF cohort and the most frequent chromosomal abnormality. The study further emphasizes the relationship between maternal age and aneuploidy. This study has important implications which help clinicians and genetic counselors in providing information in patient counseling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.