SynthesisJournal of assisted reproduction and genetics2022
The effect of extended cryo-storage following vitrification on embryo competence: a systematic review and meta-analysis.
Synthesis in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optimal timing for frozen-thawed embryo transfer: evidence from a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Impact of prolonged embryo storage on reproductive and neonatal outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Single-cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development.Clinical and translational medicine · 2026Article
- Effects of prolonged embryo cryopreservation after fertility treatment in Denmark.Reproduction & fertility · 2026Article
- Does Prolonged Preservation of Blastocysts Affect the Implantation and Live Birth Rate? A Danish Nationwide Register-Based Study.Journal of clinical medicine · 2026Article
- Effect of cryopreservation duration on pregnancy outcomes in embryos: a systematic review and meta-analysis.Human reproduction open · 2026Review
- Impact of PGT Introduction on IVF Laboratory Workload: Lessons Learned from a Single-Center Experience of 5258 Biopsies over a 10-Year Period.Life (Basel, Switzerland) · 2025Article
- DuoStim Shows Comparable Efficacy but Better Efficiency than Two Conventional Stimulations in Poor/Suboptimal Responders Undergoing Vitrified Oocyte Accumulation for PGT-A.Life (Basel, Switzerland) · 2025Article
- Patient-specific predictors of successful frozen embryo transfer using the freeze-all protocol: a retrospective observational study.Journal of Yeungnam medical science · 2025Article
- Beyond the icebox: modern strategies in organ preservation for transplantation.Clinical transplantation and research · 2024Review
- Reply: Double vitrification and warming do not compromise the chance of live birth-a potential invalid conclusion.Human reproduction open · 2024Article
- Embryo transfer impact: a comprehensive national cohort analysis comparing maternal and neonatal outcomes across varied embryo stages in fresh and frozen transfers.Frontiers in endocrinology · 2024Article
- Innovative Strategies for Fertility Preservation in Female Cancer Survivors: New Hope from Artificial Ovary Construction and Stem Cell-Derived Neo-Folliculogenesis.Healthcare (Basel, Switzerland) · 2023Review
- Effect of exposed-to-air frequency of cryopreserved embryo on clinical outcomes of vitrified-warmed embryo transfer cycles: a retrospective analysis of 9,200 vitrified-warmed transfer cycles.BMC pregnancy and childbirth · 2023Article
- Storage duration of vitrified embryos does not affect pregnancy and neonatal outcomes after frozen-thawed embryo transfer.Frontiers in endocrinology · 2023Article
- Effects of vitrified cryopreservation duration on IVF and neonatal outcomes.Journal of ovarian research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFew studies explored whether prolonged cryo-storage after vitrification affects embryo competence and perinatal outcomes. This systematic review and meta-analysis aims at highlighting any putative impact of cryo-storage duration on cryo-survival, miscarriage, live birth and major malformations.
methodsA systematic review was performed using MEDLINE (PubMed), ISI Web of Knowledge, Scopus and Embase databases up to June 2021. Data were combined to obtain a pooled OR, and meta-analysis was conducted using a random effects model. Out of 1,389 screened abstracts, 22 papers were assessed for eligibility, and 5 studies were included (N = 18,047 embryos). Prolonged cryo-storage was defined as > 12 months (N = 3389 embryos). Subgroup analysis was performed for untested vitrified cleavage stage embryos (N = 1739 embryos) and for untested and euploid vitrified blastocysts (N = 13,596 and 2712 embryos, respectively).
resultsSurvival rate, miscarriage, live birth and major malformation rates were all similar in the two groups.
conclusionThese data further support the safety of long-term cryo-storage of human embryos beyond 12 months. This is reassuring for good prognosis patients with surplus embryos, couples seeking a second child from supernumerary embryos and women postponing the transfer for clinical or personal reasons.
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Registered trials
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