Evidence map›Paper›PMID 35119514›Full record

ArticlePflugers Archiv : European journal of physiology2022

Loss of luminal carbonic anhydrase XIV results in decreased biliary bicarbonate output, liver fibrosis, and cholangiocyte proliferation in mice.

Zhenzhen Zhou, Jiajie Qian, Archana Kini, Brigitte Riederer, Dorothee Römermann, Gerolf Gros, Ursula Seidler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Zhenzhen Zhou *Department of Gastroenterology, Hannover Medical School, Hannover, Germany.
Jiajie Qian *Department of Gastroenterology, Hannover Medical School, Hannover, Germany.
Archana KiniDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
Brigitte RiedererDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
Dorothee RömermannDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
Gerolf GrosDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Ursula SeidlerDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany. Seidler.Ursula@mh-hannover.de.
Medizinische Hochschule Hannover · DETongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbonic anhydrase XIV (Car14) is highly expressed in the hepatocyte, with predominance in the canalicular membrane and its active site in the extracellular milieu. The aim of this study is to determine the physiological relevance of Car14 for biliary fluid and acid/base output, as well as its role in the maintenance of hepatocellular and cholangiocyte integrity. The common bile duct of anesthetized car14

Indexed as

BicarbonatesBile DuctsAnimalsCarbonic AnhydrasesCell ProliferationLiverLiver CirrhosisMiceBicarbonatesCarbonic Anhydrasescarbonic anhydrase XIVAcid–base balanceBicarbonateBile acidsBiliary bicarbonate umbrellaCarbonic anhydrasesElectrolyte transportLiverSclerosing cholangitis

Identifiers

PMID35119514
PMCPMC8993780
OpenAlexW4210484190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.