ArticleIntensive care medicine2022
Impact of frailty on persistent critical illness: a population-based cohort study.
Article in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06117462 (Frailty in Critical Care Unit's Patients), which is not on this map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frailty in Critical Care Unit's Patients
Who cites it
35 citing papers in PubMed.
- COVID-19 does not influence functional status after ARDS therapy.Critical care (London, England) · 2023Trial
- Recognise, respond, reflect: A value-based framework for rapid response teams.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Long-term survival of patients with persistent critical illness in Australia and New Zealand; a retrospective registry-based cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Association between hospital frailty risk score and in-hospital mortality in critically ill patients with sepsis: results from MIMIC-IV database.Scientific reports · 2026Article
- Persistent critical illness in acute hypoxic respiratory failure: A retrospective cohort study.PloS one · 2026Article
- Life-threatening immune-related adverse events in the intensive care unit: a narrative review.Intensive care medicine · 2025Review
- Rinaldo Bellomo and the evolution of critical care survivorship.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Timing of onset of persistent critical illness in Japan: a nationwide registry study.The Lancet regional health. Western Pacific · 2025Article
- Prevalence of frailty and its effect on requirement of organ support and clinical outcomes in critically ill patients: a prospective observational single center study.BMC anesthesiology · 2025Observational
- Prevalence of New Frailty at Hospital Discharge in Severe COVID-19 Survivors and Its Associated Factors.Tuberculosis and respiratory diseases · 2025Article
- The pictorial fit-frail scale: a novel tool for frailty assessment in critically ill older adults.BMC geriatrics · 2025Article
- Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice.Critical care (London, England) · 2024Article
- Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005-2022. A binational, registry-based study.Intensive care medicine · 2024Article
- Frailty in the cardiac intensive care unit: assessment and impact.European heart journal. Acute cardiovascular care · 2024Review
- Prevalence and long-term outcomes of patients with life-limiting illness admitted to intensive care units in Australia and New Zealand.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- The truism of 'life limiting illness' in ICU.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Inflammaging in Multidrug-Resistant Sepsis of Geriatric ICU Patients and Healthcare Challenges.Geriatrics (Basel, Switzerland) · 2024Review
- Persistent Critical Illness and Long-Term Outcomes in Patients With COVID-19: A Multicenter Retrospective Cohort Study.Critical care explorations · 2024Article
- Long-stay ICU patients with frailty: mortality and recovery outcomes at 6 months.Annals of intensive care · 2024Article
- The critically ill older patient with sepsis: a narrative review.Annals of intensive care · 2024Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcute illness severity predicts mortality in intensive care unit (ICU) patients, however, its predictive value decreases over time in ICU. Typically after 10 days, pre-ICU (antecedent) characteristics become more predictive of mortality, defining the onset of persistent critical illness (PerCI). How patient frailty affects development and death from PerCI is unknown.
methodsWe conducted a secondary analysis of data from a prospective binational cohort study including 269,785 critically ill adults from 168 ICUs in Australia and New Zealand, investigating whether frailty measured with the Clinical Frailty Scale (CFS) changes the timing of onset and risk of developing PerCI and of subsequent in-hospital mortality. We assessed associations between frailty (CFS ≥ 5) and mortality prediction using logistic regression and area under the receiver operating characteristics (AUROC) curves.
results2190 of 50,814 (4.3%) patients with frailty (CFS ≥ 5) versus 6624 of 218,971 (3%) patients without frailty (CFS ≤ 4) developed PerCI (P < 0.001). Among patients with PerCI, 669 of 2190 (30.5%) with frailty and 1194 of 6624 without frailty (18%) died in hospital (P < 0.001). The time point defining PerCI onset did not vary with frailty degree; however, with increasing length of ICU stay, inclusion of frailty progressively improved mortality discrimination (0.1% AUROC improvement on ICU day one versus 3.6% on ICU day 17).
conclusionCompared to patients without frailty, those with frailty have a higher chance of developing and dying from PerCI. Moreover the importance of frailty as a predictor of mortality increases with ICU length of stay. Future work should explore incorporation of frailty in prognostic models, particularly for long-staying patients.
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