ArticleDiabetologia2022
Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation-relevance for (pre)diabetes: The Maastricht Study.
Article in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Less Is More? Physical Inactivity and Increased Risk of Diabetes-Related Foot Ulceration-A Systematic Review.Diabetes/metabolism research and reviews · 2026Pooled it
- The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2024Pooled it
- Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2023Pooled it
- The effect of smoking on lung function changes during a 16-week combined exercise program in middle-aged workers: a latent growth curve analysis.European journal of applied physiology · 2025Trial
- Longitudinal transitions in sedentary behavior and physical activity in relation to all-cause and cause-specific mortality among postmenopausal women.GeroScience · 2026Observational
- Accelerometry-measured prolonged and interrupted sedentary behavior and cancer incidence and mortality: A cohort study of 91,292 UK Biobank participants.PLoS medicine · 2026Article
- Accelerometer-derived "weekend warrior" physical activity pattern and trajectory of cardio-renal-metabolic multimorbidity: a multi-state analysis in the UK Biobank.BMC public health · 2026Article
- Salivary vascular growth factor responses to prolonged and interrupted sitting in young, healthy adults.Physiological reports · 2026Article
- The Association Between Sedentary Behavior and Cardiovascular Disease Risk: An Analysis Based on NHANES Data.Cardiovascular therapeutics · 2026Article
- Pathological mechanisms and clinical research progress of endothelial dysfunction.Frontiers in cardiovascular medicine · 2026Review
- Joint association of inflammatory markers and sedentary time with mortality in metabolic dysfunction-associated steatotic liver disease population and the mediating role of inflammation.European journal of medical research · 2025Article
- Global trends and modifiable risk factors for atopic dermatitis incidence: Insights from GBD 2021.The journal of allergy and clinical immunology. Global · 2025Article
- Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis.International journal of molecular sciences · 2025Review
- Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study.Molecular neurobiology · 2025Article
- Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour-The Maastricht Study.Diabetes/metabolism research and reviews · 2025Article
- Association between novel inflammatory biomarkers SII, SIRI, and obesity in sedentary adults: NHANES 2007-2020.Scientific reports · 2025Article
- Article
- Association of oxidative balance score with the risk of all-cause and CVD mortality in younger US adults with diabetes.Scientific reports · 2025Article
- Endothelial Dysfunction in Acute Myocardial Infarction: A Complex Association With Sleep Health, Traditional Cardiovascular Risk Factors and Prognostic Markers.Clinical cardiology · 2025Article
- Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisBiomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be especially prominent in type 2 diabetes.
methodsIn the population-based Maastricht Study (n = 2363, 51.5% male, 28.3% type 2 diabetes, 15.1% prediabetes [defined as impaired glucose tolerance and impaired fasting glucose]), we determined biomarkers of endothelial dysfunction and low-grade inflammation, and combined z scores were calculated. Physical activity and sedentary behaviour were measured by activPAL. Linear regression analyses were used with adjustment for demographic, lifestyle and cardiovascular risk factors.
resultsThe association between total, light, moderate-to-vigorous and vigorous intensity physical activity and sedentary time on the one hand and biomarkers of endothelial dysfunction on the other were generally significant and were consistently stronger in prediabetes and type 2 diabetes as compared with normal glucose metabolism status (p for interaction <0.05). Associations between physical activity and sedentary behaviour on the one hand and low-grade inflammation on the other were also significant and were similar in individuals with and without (pre)diabetes (p for interaction >0.05). CONCLUSIONS/
interpretationPhysical activity and sedentary behaviour are associated with biomarkers of endothelial dysfunction and low-grade inflammation. For biomarkers of endothelial dysfunction, associations between physical activity and sedentary behaviour were consistently stronger in (pre)diabetes than in normal glucose metabolism. Whether increasing physical activity or decreasing sedentary time can positively influence biomarkers of endothelial dysfunction in individuals with prediabetes and type 2 diabetes requires further study.
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