Evidence map›Paper›PMID 35119366›Full record

ArticleeLife2022

The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in

Josh Saul, Takashi Hirose, H Robert Horvitz

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Josh SaulDepartment of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, United States.ORCID 0000-0003-4193-497X
Takashi HiroseDepartment of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, United States.
H Robert HorvitzDepartment of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, United States.ORCID 0000-0002-9964-9613
Howard Hughes Medical Institute · US

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral SystemsR01GM024663 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HORVITZ, H ROBERT · 1985 to 2025
$10.1M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
GENETIC ANALYSIS OF NEMATODE EGG-LAYINGR37GM024663 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HORVITZ, H R · 1991 to 2000
$363k
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM024663NIGMS NIH HHS R37 GM024663NIGMS NIH HHS T32 GM007287NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cell identity is characterized by a distinct combination of gene expression, cell morphology, and cellular function established as progenitor cells divide and differentiate. Following establishment, cell identities can be unstable and require active and continuous maintenance throughout the remaining life of a cell. Mechanisms underlying the maintenance of cell identities are incompletely understood. Here, we show that the gene

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationGene Expression Regulation, DevelopmentalInterneuronsRepressor ProteinsSOXD Transcription FactorsTranscription FactorsCaenorhabditis elegans ProteinsCTBP-1 protein, C elegansRepressor ProteinsSOXD Transcription FactorsTranscription FactorsC. eleganscell fatecell-identity maintenancedevelopmental biologygeneticsgenomicstranscriptional corepressor

Identifiers

PMID35119366
PMCPMC8816384
OpenAlexW4210632643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.