Evidence map›Paper›PMID 35118823›Full record

ArticleESC heart failure2022

Improving diagnosis and risk stratification across the ejection fraction spectrum: the Maastricht Cardiomyopathy registry.

Michiel T H M Henkens, Jerremy Weerts, Job A J Verdonschot, Anne G Raafs, Sophia Stroeks, Maurits A Sikking, Hesam Amin, Sanne G J Mourmans, Chrit B G Geraeds, Sandra Sanders-van Wijk and 18 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04976348 (The Multicenter Cardiology Monitoring Platform Registry), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04976348 recruitingnot on this map

The Multicenter Cardiology Monitoring Platform Registry (mCMP-registry)

Typeobservational_patient_registrySponsorMaastricht University Medical CenterRan2021 to 2051Enrolled40,000ConditionsHeart Failure, Cardiomyopathies, Atrial Fibrillation, Ventricular Arrythmia
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. The Dutch cardiomyopathy registry (DCR); rationale and registry design.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Article
  3. Article
  4. Predictive value of ambulatory ECG monitoring for malignant arrhythmic events in genetic dilated cardiomyopathy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  5. High societal costs and reduced health-related quality of life in inflammatory and systemic immune disease-associated dilated cardiomyopathies.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Observational
  13. Quality of life and societal costs in patients with dilated cardiomyopathy.European heart journal. Quality of care & clinical outcomes · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 4 institutions in 3 countries.

Michiel T H M HenkensDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Jerremy WeertsDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Job A J VerdonschotDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Anne G RaafsDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Sophia StroeksDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Maurits A SikkingDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Hesam AminDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Sanne G J MourmansDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Chrit B G GeraedsDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Sandra Sanders-van WijkDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Arantxa Barandiarán AizpuruaDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Nicole H M K Uszko-LencerDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Ingrid P C KrapelsDepartment of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands.
Petra F G WolffsDepartment of Medical Microbiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Han G BrunnerDepartment of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands.
Rick E W van LeeuwenDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Wouter VerhesenDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Simon M SchallaDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Antonius W M van StipdonkDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Christian KnackstedtDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Xiaofei LiDepartment of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Myrurgia A Abdul HamidDepartment of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Pieter van PaassenDepartment of Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, The Netherlands.
Mark R HazebroekDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Kevin VernooyDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Hans-Peter Brunner-La RoccaDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Vanessa P M van EmpelDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Stephane R B HeymansDepartment of Cardiology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Maastricht University Medical Centre · NLEquilibrium Research · GBMaastricht University · NLZuyderland Medisch Centrum · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHeart failure (HF) represents a clinical syndrome resulting from different aetiologies and degrees of heart diseases. Among these, a key role is played by primary heart muscle disease (cardiomyopathies), which are the combination of multifactorial environmental insults in the presence or absence of a known genetic predisposition. The aim of the Maastricht Cardiomyopathy registry (mCMP-registry; NCT04976348) is to improve (early) diagnosis, risk stratification, and management of cardiomyopathy phenotypes beyond the limits of left ventricular ejection fraction (LVEF). METHODS AND

resultsThe mCMP-registry is an investigator-initiated prospective registry including patient characteristics, diagnostic measurements performed as part of routine clinical care, treatment information, sequential biobanking, quality of life and economic impact assessment, and regular follow-up. All subjects aged ≥16 years referred to the cardiology department of the Maastricht University Medical Center (MUMC+) for HF-like symptoms or cardiac screening for cardiomyopathies are eligible for inclusion, irrespective of phenotype or underlying causes. Informed consented subjects will be followed up for 15 years. Two central approaches will be used to answer the research questions related to the aims of this registry: (i) a data-driven approach to predict clinical outcome and response to therapy and to identify clusters of patients who share underlying pathophysiological processes; and (ii) a hypothesis-driven approach in which clinical parameters are tested for their (incremental) diagnostic, prognostic, or therapeutic value. The study allows other centres to easily join this initiative, which will further boost research within this field.

conclusionsThe broad inclusion criteria, systematic routine clinical care data-collection, extensive study-related data-collection, sequential biobanking, and multi-disciplinary approach gives the mCMP-registry a unique opportunity to improve diagnosis, risk stratification, and management of HF and (early) cardiomyopathy phenotypes beyond the LVEF limits.

Indexed as

CardiomyopathiesQuality of LifeBiological Specimen BanksHumansRegistriesRisk AssessmentStroke VolumeVentricular Function, LeftCardiomyopathiesDiagnosisHeart failurePrognosisRegistry

Identifiers

PMID35118823
PMCPMC8934928
OpenAlexW4210665160

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.