ArticleJournal of veterinary internal medicine2022
Evaluation of resting cortisol concentration testing in dogs with chronic gastrointestinal signs.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Factors Affecting Hair Cortisol Concentration in Domestic Dogs: A Focus on Factors Related to Dogs and Their Guardians.Animals : an open access journal from MDPI · 2025Article
- Comparison between typical primary and eunatraemic, eukalaemic hypoadrenocorticism: 92 cases.Irish veterinary journal · 2024Article
- Can we predict hypoadrenocorticism in dogs with resting hypocortisolemia? A predictive model based on clinical, haematological, and biochemical variables.Frontiers in veterinary science · 2024Article
- Evaluation of a machine learning tool to screen for hypoadrenocorticism in dogs presenting to a teaching hospital.Journal of veterinary internal medicine · 2022Article
- Evaluation of resting cortisol concentration testing in dogs with chronic gastrointestinal signs.Journal of veterinary internal medicine · 2022Article
- Prevalence of eunatremic, eukalemic hypoadrenocorticism in dogs with signs of chronic gastrointestinal disease and risk of misdiagnosis after previous glucocorticoid administration.Journal of veterinary internal medicineArticle
- Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse.Journal of veterinary internal medicineArticle
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundResting cortisol concentrations are routinely measured in dogs with chronic gastrointestinal signs to rule out hypoadrenocorticism based on a concentration >2 μg/dL (>55 nmol/L). HYPOTHESIS/
objectivesTo assess the cross-sectional prevalence of hypoadrenocorticism in a group of dogs with chronic gastrointestinal signs presented to a referral internal medicine service. ANIMALS: Two-hundred and eighty-two client-owned dogs with chronic gastrointestinal signs and with resting cortisol concentration testing performed.
methodsRetrospective review of medical records (final diagnosis, resting cortisol concentration, and adenocorticotropic hormone [ACTH] stimulation test results) of a referral population of dogs between May 2013 and September 2017.
resultsResting cortisol concentration was <2 μg/dL (<55 nmol/L) in 79 patients (28%). Repeated resting cortisol concentration measurements were performed in 28 dogs, and in 8, resting cortisol concentrations remained <2 μg/dL (<55 nmol/L). Post-ACTH cortisol concentration was <2 μg/dL (<55 nmol/L) in 1 dog, consistent with a diagnosis of hypoadrenocorticism and giving a prevalence estimate of hypoadrenocorticism in this population of dogs of 0.3% (95% confidence interval [95CI], 0.03-1.5%). In 19 dogs with an initial resting cortisol concentration <2 μg/dL (<55 nmol/L), hypoadrenocorticism was excluded based on a repeat resting cortisol concentration >2 μg/dL (>55 nmol/L). Overall, the most common diagnosis was chronic primary inflammatory enteropathy (176/282, 62.4%), followed by extragastrointestinal neoplasia (17/282, 6%), protein-losing enteropathy, pancreatitis and megaesophagus (10/282, 3.5% each). CONCLUSIONS AND CLINICAL IMPORTANCE: Although dogs with hypoadrenocorticism can present with chronic gastrointestinal signs, it was the final diagnosis in only 1 of 282 dogs presenting to a referral internal medicine service for signs of chronic enteropathy. Repeated resting cortisol concentration may be considered as a test to try and exclude hypoadrenocorticism.
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