ArticlePediatric nephrology (Berlin, Germany)2022
Widespread kidney anomalies in children with Down syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Kidney and urogenital abnormalities in Down syndrome: a meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Age- and sex-specific serum creatinine reference curves in children and adolescents with Down syndrome.European journal of pediatrics · 2026Article
- Rethinking Creatinine in Children With Down Syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Serum Creatinine Levels in Children With Down Syndrome: A Single-Centre Retrospective Study in Ireland.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Down Syndrome: From Pregnancy through Childhood in Türkiye.Molecular syndromology · 2026Article
- Acute kidney injury and chronic kidney disease in individuals with Down syndrome: a nationwide cohort study.Clinical kidney journal · 2026Article
- Navigating Genetic Testing in Nephrology: Options and Decision-Making Strategies.Kidney international reports · 2025Review
- Review
- Kidney Function and Size in Children With Down Syndrome: A Cross-Sectional Study.Nephrology (Carlton, Vic.) · 2025Article
- Perioperative Acute Kidney Injury and Prognosis of Infants With Down Syndrome and Congenital Heart Disease.Cureus · 2024Article
- The role of the mitochondrial trans-sulfuration in cerebro-cardio renal dysfunction during trisomy down syndrome.Molecular and cellular biochemistry · 2024Review
- Creatinine levels in French children with Down syndrome up to ten years old.European journal of pediatrics · 2024Article
- Kidney and urological involvement in Down syndrome: frequent, underestimated, but associated with impaired quality of life and risk of kidney failure.Pediatric nephrology (Berlin, Germany) · 2024Review
- Article
- Long-Term Non-Congenital Cardiac and Renal Complications in Down Syndrome: A Study of 32,936 Patients.Children (Basel, Switzerland) · 2023Article
- CAKUT: A Pediatric and Evolutionary Perspective on the Leading Cause of CKD in Childhood.Pediatric reports · 2023Review
- Procoagulant Activity in Amniotic Fluid Is Associated with Fetal-Derived Extracellular Vesicles.Current issues in molecular biology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRare autopsy studies have described smaller kidneys as well as urinary tract anomalies in Down syndrome. This observation has never been investigated in vivo and little is known about the possible consequences upon kidney function. Here we wish to confirm whether children with Down syndrome have smaller kidneys and to evaluate their kidney function in vivo.
methodsThis retrospective cohort study enrolled 49 children with Down syndrome, as well as 49 age- and sex-matched controls at the Queen Fabiola Children's University Hospital in Brussels, Belgium. Doppler and kidney ultrasonography, spot urine albumin to creatinine ratio, estimated glomerular filtration rate (eGFR), and anthropometric data were recorded.
resultsKidney size in children with Down syndrome was smaller than age- and sex-matched controls in terms of length (p < 0.001) and volume (p < 0.001). Kidney function based on eGFR was also decreased in Down syndrome compared to historical normal. Twenty-one of the children with Down syndrome (42%) had eGFR < 90 mL/min/1.73 m
conclusionsChildren with Down syndrome have significantly smaller kidneys than age-matched controls as well as evidence of decreased kidney function. These findings, in addition to well-noted increased kidney and urologic anomalies, highlight the need for universal anatomical and functional assessment of all individuals with Down syndrome. A higher resolution version of the Graphical abstract is available as Supplementary information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.