Evidence map›Paper›PMID 35118479›Full record

ArticlemedRxiv : the preprint server for health sciences2022

COVID-19 vaccination recruits and matures cross-reactive antibodies to conserved epitopes in endemic coronavirus Spike proteins.

Evan A Elko, Georgia A Nelson, Heather L Mead, Erin J Kelley, Virginia Le Verche, Angelo A Cardoso, Jennifer L Ely, Annalee S Boyle, Alejandra Piña, Sierra N Henson and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Evan A ElkoThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Georgia A NelsonThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Heather L MeadThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Erin J KelleyThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Virginia Le VercheCenter for Gene Therapy, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, CA, USA.
Angelo A CardosoCenter for Gene Therapy, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, CA, USA.
Jennifer L ElyThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Annalee S BoyleThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Alejandra PiñaThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Sierra N HensonThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Fatima RaheeThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Paul S KeimThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Kimberly R CelonaThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Jinhee YiThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Erik W SettlesThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
George C YuGeorge C Yu, MD, Inc., Camarillo, CA.
Sheldon R MorrisUniversity of California San Diego CIRM Alpha Stem Cell Clinic, La Jolla, CA.
John A ZaiaCenter for Gene Therapy, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, CA, USA.
Jason T LadnerThe Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
John A AltinThe Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Translational Genomics Research Institute · USNorthern Arizona University · USCity Of Hope National Medical Center · USUniversity of California San Diego · US

Funding

A scalable platform for highly-multiplexed analysis of antibody reactivity from <1uL of bloodU24AI152172 · NIAID · TRANSLATIONAL GENOMICS RESEARCH INST · PI ALTIN, JOHN · 2020 to 2024
$3.3M
NIAID NIH HHS U24 AI152172
6 · The paper itself

Abstract

The COVID-19 pandemic has triggered the first widespread vaccination campaign against a coronavirus. Most vaccinated subjects are naïve to SARS-CoV-2, however almost all have previously encountered other coronaviruses (CoVs) and the role of this immunity in shaping the vaccine response remains uncharacterized. Here we use longitudinal samples and highly-multiplexed serology to identify mRNA-1273 vaccine-induced antibody responses against a range of CoV Spike epitopes and in both phylogenetically conserved and non-conserved regions. Whereas reactivity to SARS-CoV-2 epitopes showed a delayed but progressive increase following vaccination, we observed distinct kinetics for the endemic CoV homologs at two conserved sites in Spike S2: these became detectable sooner, and decayed at later timepoints. Using homolog-specific depletion and alanine-substitution experiments, we show that these distinctly-evolving specificities result from cross-reactive antibodies as they mature against rare, polymorphic residues within these epitopes. Our results reveal mechanisms for the formation of antibodies with broad reactivity against CoVs.

Identifiers

PMID35118479
PMCPMC8811912
OpenAlexW4210569260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.