ArticleMediastinum (Hong Kong, China)2019
Levels of Tc17 cells in thymic epithelial cell tumors associated with autoimmune diseases.
Article in Mediastinum (Hong Kong, China), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThymomas are thymic epithelial cell tumors. Between 4% and 7% of thymomas develop in patients with two or more concomitant diseases of the thymus, the vast majority of which are autoimmune disorders such as myasthenia gravis (MG). Tc17cells and Th17cells have been shown play an important role in the development of tumors and autoimmune diseases (ADs).
methodsWe assessed the distribution of Tc17cells in thymic epithelial tumors and the thymic expression of retinoid-related orphan receptor-γt (RORγt) in patients with thymic epithelial tumors as well as MG or other ADs. We also assessed the frequency of Th17/Tc17 cells in peripheral blood mononuclear cells (PBMCs).
resultsCD8
conclusionsTogether, these data suggest that Th17/Tcl7 cells are involved in antitumor immunity and autoimmune disorders, which may offer a path toward development of improved immunotherapies.
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