Evidence map›Paper›PMID 35118188›Full record

ArticleSSM - population health2022

Quantitative methods for descriptive intersectional analysis with binary health outcomes.

Mayuri Mahendran, Daniel Lizotte, Greta R Bauer

Abstract read
In one paragraph

Article in SSM - population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. From Averages to Heterogeneity: A Plain-Language Guide to MAIHDA in Epidemiology.International journal of social determinants of health and health services · 2026
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  15. Sociodemographic characteristics of maternal presence in neonatal intensive care: an intersectional analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mayuri MahendranEpidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Canada.
Daniel LizotteEpidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Canada.
Greta R BauerEpidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intersectionality recognizes that in the context of sociohistorically shaped structural power relations, an individual's multiple social positions or identities (e.g., gender, ethnicity) can interact to affect health-related outcomes. Despite limited methodological guidance, intersectionality frameworks have increasingly been incorporated into epidemiological studies, both to describe health disparities and to examine their causes. This study aimed to advance methods in intersectional estimation of binary outcomes in descriptive health disparities research through evaluation of 7 potentially intersectional data analysis methods: cross-classification, regression with interactions, multilevel analysis of individual heterogeneity (MAIHDA), and decision trees (CART, CTree, CHAID, random forest). Accuracy of estimated intersection-specific outcome prevalence was evaluated across 192 intersections using simulated data scenarios. For comparison we included a non-intersectional main effects regression. We additionally assessed variable selection performance amongst decision trees. Example analyses using National Health and Nutrition Examination Study data illustrated differences in results between methods. At larger sample sizes, all methods except for CART performed better than non-intersectional main effects regression. In smaller samples, MAIHDA was the most accurate method but showed no advantage over main effects regression, while random forest, cross-classification, and saturated regression were the least accurate, and CTree and CHAID performed moderately well. CART performed poorly for estimation and variable selection. Sensitivity analyses examining the bias-variance tradeoff suggest MAIHDA as the preferred unbiased method for accurate estimation of high-dimensional intersections at smaller sample sizes. Larger sample sizes are more imperative for other methods. Results support the adoption of an intersectional approach to descriptive epidemiology.

Indexed as

BiostatisticsCART, classification and regression treeCHAID, chi-square automatic interaction detectorCTree, conditional inference treesEpidemiological studiesHealth equityIntersectionalityMAD, mean absolute deviationMAIHDA, multilevel analysis of individual heterogeneity and discriminatory accuracyNHANES, National Health and Nutrition Examination StudyResearch designSD, standard deviationU.S., United StatesVIM, variable importance measure

Identifiers

PMID35118188
PMCPMC8800141

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.