Evidence map›Paper›PMID 35118008›Full record

ArticleFrontiers in cellular and infection microbiology2021

Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of

Emil Aagaard Thomsen, Sofie Andersen, Mikkel Haarslev Schröder Marqvorsen, Kristian Alsbjerg Skipper, Søren R Paludan, Jacob Giehm Mikkelsen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Emil Aagaard ThomsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Sofie AndersenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Mikkel Haarslev Schröder MarqvorsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Kristian Alsbjerg SkipperDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Søren R PaludanDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Jacob Giehm MikkelsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Aarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The innate immune system represents a balanced first line of defense against infection. Type I interferons (IFNs) are key regulators of the response to viral infections with an essential early wave of IFN-β expression, which is conditional, time-restricted, and stochastic in its nature. The possibility to precisely monitor individual cells with active

Indexed as

Interferon-betaInterferon Type IImmunity, InnatePromoter Regions, GeneticSignal TransductionInterferon-betaInterferon Type Iflow cytometryIFNB1 reporterIFNB1 transcriptioninnate immunitysingle-cell

Identifiers

PMID35118008
PMCPMC8803904
OpenAlexW4205257560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.