ArticleTranslational cancer research2020
Radical local treatment for stage IV non-small cell lung cancer in older adults: a propensity-score matched analysis of the SEER database.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Comparative real-world survival of first-line atezolizumab, nivolumab, and pembrolizumab in older patients with metastatic non-small cell lung cancer.Journal of managed care & specialty pharmacy · 2025Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased incidence of lung cancer in older adults is attributed to increased life expectancy, increased risk for many types of cancer, age-associated comorbidities and physical performance status. Contraindicatory tumor resection is suggested to benefit survival outcomes in stage IV non-small-cell lung cancer (NSCLC). We analyzed the clinical characteristics of older adults ≥70 years old with stage IV NSCLC and investigated whether radical local treatment may benefit this population.
methodsThis retrospective, population-based cohort study analyzed patient data from the USA Surveillance, Epidemiology and End Results (SEER) Program during 2004-2016. Eligible patients were aged ≥70 years and diagnosed with stage IV NSCLC. Primary endpoints were overall survival (OS) and lung-cancer-specific survival (LCSS). Propensity-score matching (PSM) and Cox regression analysis were performed to assess the prognostic role of surgical resection of primary tumor or metastasis.
resultsAmong 54,310 stage IV NSCLC older patients, 7.50% received radical local treatment of the primary tumor or metastasis. PSM resulted in a balanced study population consisting of a treatment group (n=4,037) and a matched no-local-treatment group (n=15,658). After adjusting for confounders, radical local treatment was significantly associated with increased LCSS [hazard ratio (HR): 0.85, 95% confidence interval (95% CI): 0.72-1.00] but decreased OS (HR: 1.97, 95% CI: 1.31-2.97, P=0.0012).
conclusionsIn older adults ≥70 years old with stage IV NSCLC, radical local treatment is associated with increased LCSS but decreased OS. Additional prospective studies are warranted to confirm the benefit of radical local treatment for primary or metastatic NSCLC.
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