ArticleTranslational cancer research2020
Expression of combined interference of slug and FoxC2 in endometrial carcinoma and its clinicopathological relationship.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Insights into the Molecular Mechanisms and Signaling Pathways of Epithelial to Mesenchymal Transition (EMT) in the Pathophysiology of Endometriosis.International journal of molecular sciences · 2025Review
- BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.PeerJ · 2025Article
- LINC01305 recruits basonuclin 1 to act on G-protein pathway suppressor 1 to promote esophageal squamous cell carcinoma.Cancer science · 2023Article
- Molecular expression of Forkhead Box C2 gene (FOXC2) and Prospero homeobox gene (PROX-1) in oral squamous carcinoma and their correlation with clinicopathological parameters: A prospective cohort study.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial carcinoma is one of the three major malignant tumors in female reproductive system. The current research aimed to investigate the relationship between the Slug and FoxC2 expression and the proliferation, invasion and metastasis of endometrial carcinoma.
methodsThe expression of
resultsCompared with normal endometrial tissues, the Slug and FoxC2 expression levels in endometrial carcinoma tissues were remarkably increased. shRNAs transfection significantly down-regulated expressions in both endometrial carcinoma cell lines. The proliferation, invasion and migration ability were significantly inhibited by Slug-shRNA and FoxC2-shRNA compared with the control group. The expression of E-cadherin was increased while the expression of N-cadherin, Vimentin, MMP-2 and MMP-9 was suppressed by the Slug-shRNA and FoxC2-shRNA.
conclusionsSlug and FoxC2 could be used as a prognostic factor of endometrial carcinoma. Interfering with the expression of Slug and FoxC2 in endometrial carcinoma cell lines could effectively inhibit the proliferation, invasion and migration, and its mechanism is related to the inhibition of EMT. Slug and FoxC2 are potential targets for the treatment of endometrial carcinoma.
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