ArticleTranslational cancer research2020
The expression of Fibulin-3 in ovarian cancer and its relationship with prognosis.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- UCHL3 regulates snail stability and promotes epithelial-mesenchymal transition in ovarian cancer.Cytotechnology · 2025Article
- Significance of fibulin-3 expression in bladder cancer: a tissue microarray-based immunohistochemical study.World journal of surgical oncology · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundDespite the significant advancements made in the treatment of ovarian cancer (OC), poor prognosis remains a major concern because this disease is frequently diagnosed at an advanced stage. Tumor recurrence and metastasis have been implicated in the poor clinical outcomes of OC. Although Fibulin-3 has been shown to be closely related to the development of various tumors, its relationship with OC has not been widely examined. Hence, this study was conducted to investigate the expression of Fibulin-3 in epithelial ovarian cancer (EOC), determine its relationship with EOC prognosis, and correlate its expression with that of the epithelial-mesenchymal transition markers (Snail, E-cadherin, and N-cadherin).
methodsImmunohistochemistry analysis was performed to detect the expression of Fibulin-3 protein in 84 OC samples, 10 benign ovarian tumor samples, and eight borderline ovarian tumor samples.
resultsThe positive rates of Fibulin-3 protein expression in OC, benign ovarian tumors, and borderline ovarian tumors were 45.24%, 20%, and 0%, respectively, showing significant differences (P<0.05). Fibulin-3 expression was found to be correlated with the FIGO stage of EOC, with tumors in higher stages (FIGO III + IV) showing higher expression. Additionally, at the protein level, Fibulin-3 was negatively correlated with E-cadherin protein (r=-0.252, P<0.05), and positively correlated with Snail and N-cadherin protein (r=0.644, 0.451, P<0.01).Overexpression of Fibulin-3 and the FIGO stage (III + IV) were related to the poor prognosis of patients (P<0.05). High expression of Fibulin-3 was an independent prognostic factor of EOC (P<0.05) The survival curve analysis showed that patients overexpressing Fibulin-3 had significantly shorter survival than those with low expression (P<0.05).
conclusionsIncreased expression of Fibulin-3 was found to be related to the invasion, metastasis, and prognosis of ovarian tumors, suggesting that it is an important indicator for evaluating the clinical prognosis of patients with EOC.
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