ArticleTranslational cancer research2020
Application of next-generation sequencing in resistance genes of neoadjuvant chemotherapy for esophageal cancer.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Genomic alterations and dynamic molecular residual disease monitoring predict pathological response to neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma.Frontiers in immunology · 2026Article
- Biofunctional study on chemoresistance in esophageal squamous carcinoma cells induced by missense mutation ofJournal of thoracic disease · 2024Article
- Changes of proportions of circulating lymphocyte subsets in cancer patients after chemotherapy.Translational cancer research · 2021Article
- The Notch1 gene may control cell chemoresistance in esophageal squamous cell cancer.Translational cancer research · 2021Article
- Advances in Drug Resistance of Esophageal Cancer: From the Perspective of Tumor Microenvironment.Frontiers in cell and developmental biology · 2021Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeoadjuvant chemotherapy (NAC) has been proven to effectively improve the prognosis and long-term survival of patients with esophageal cancer (EC). But approximately 40% of patients are relatively insensitive to NAC. The mechanism underlying gene-induced resistance remains elusive.
methodsWe conducted a cohort of 13 NAC patients with different chemotherapy responses to identify gene mutations related to drug resistance by next-generation sequencing (NGS) of samples from patients with EC. We performed protein conformation on these mutant genes to figure out the possible mechanisms related to resistance.
resultsOur results indicated that missense mutations were commonly emerged in patients with partial response (PR) and stable disease (SD). Moreover,
conclusionsWe analyzed the effect of platinum-based NAC on gene mutations in patients with EC and find that mutations in somatic genes, especially the
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