ArticleTranslational cancer research2020
The efficacy of Raman spectroscopy in the diagnosis of esophageal cancer: a systematic review and meta-analysis.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- System transferability of Raman-based oesophageal tissue classification using modern machine learning to support multi-centre clinical diagnostics.BJC reports · 2024Article
- On-chip Raman spectroscopy of live single cells for the staging of oesophageal adenocarcinoma progression.Scientific reports · 2024Article
- [Diagnostic Study of Multi-spectral Intelligent Analyzer in Diagnosis of the Infiltration Degree of Lung Adenocarcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophageal cancer is characterized by its high occurrence rate and difficulty to treat successfully, therefore early diagnosis is extremely important. Our article is aimed to comprehensively analyze the relative effectiveness of Raman spectroscopy (RS) in the diagnosis of suspected esophageal cancer.
methodsWe performed a systemic search in PubMed, EMBASE, CNKI and Web of science from 2007 to 2020. We used the diagnostic data of true positive (TP), false positive (FP), true negative (TN) and false negative (FN) to estimate the pooled sensitivity, specificity, positive and negative likelihood ratios (LR), and diagnostic odds ratio (DOR), with 95% confidence intervals (CI), based on random effects models. The SROC curve analysis and AUC were performed to estimate the overall performance of Raman spectroscopy. QUADAS-2 guidelines were used to evaluate the quality of each study.
resultsNine articles were included according to our inclusion and exclusion criteria. General pooled diagnostic sensitivity and specificity of RS to esophageal cancer were 0.91 (95% CI, 0.89-0.93) and 0.92 (95% CI, 0.91-0.94). The pooled PLR and NLR were 18.98 (95% CI, 6.61-54.49) and 0.09 (95% CI, 0.05-0.16), respectively. The DOR was 217.21 (95% CI, 68.32-690.53) indicating high accuracy. And the AUC of SROC curve was 0.9779.
conclusionsWe found a promisingly high sensitivity and specificity of RS in the diagnosis of suspected esophageal mass.
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