ArticleTranslational cancer research2020
SUMO1 modification of histone H4 is involved in the pathogenesis of nodular lymphocyte predominant Hodgkin lymphoma.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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- The therapeutic effect and specific mechanism involved active Chinese medicine component biochaninA in glioma.Frontiers in immunology · 2026Article
- Improving predictive accuracy in multiple myeloma using a plasma cell profile derived from single-cell RNA sequencing.Haematologica · 2025Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundNodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a distinct and rare subtype of Hodgkin lymphoma (HL) that can be differentially diagnosed from classical Hodgkin lymphoma (cHL). Because of its low prevalence rate and undefined pathogenic mechanisms, a specific treatment for NLPHL has yet to be determined. In NLPHL, which is a malignant B-cell lymphoma, antigen stimulation results in the formation of germinal centers by secondary lymphoid follicles, which promotes the differentiation of germinal center B cells (GCBs) into long-lived plasma cells and memory B cells. Any abnormality during the differentiation can lead to the occurrence and development of NLPHL.
methodsThe GDS4977 data set was selected from the Gene Expression Omnibus (GEO) repository. Differentially-expressed genes (DEGs) were detected with GEO2R. Gene Ontology (GO) enrichment analysis of biological processes (BP) and Reactome pathways was performed withg:Profile. Cytoscape software was employed to screen hub genes, while the core genes were determined using the STRING and Reactome databases.
resultsIn total, 623 DEGs, 68 GO-BP pathways, 70 Reactome pathways, 19 hub genes, and 12 core genes were identified.
conclusionsHistone expressions differ between NLPHL and GCBs, and
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