ArticleTranslational cancer research2020
Positive lymph node ratio as a novel indicator of prognosis in gastric signet ring cell carcinoma: a population-based retrospective study.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Survival Outcome of Gastric Signet Ring Cell Carcinoma Based on the Optimal Number of Examined Lymph Nodes: A Nomogram- and Machine-Learning-Based Approach.Journal of clinical medicine · 2023Article
- Pathological Nodal Staging Score for Gastric Signet Ring Cell Carcinoma: A Clinical Tool of Adequate Nodal Staging.Diagnostics (Basel, Switzerland) · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundLymph node status has a strong predictive effect on the prognosis of all patients with gastric cancer. It is unclear whether the positive lymph node ratio (PLNR) is a reliable prognostic factor for gastric signet ring cell carcinoma (SRCC).
methodsPatients with SRCC were obtained from the Surveillance, Epidemiology and End Results (SEER) database for the years 1998-2013. Cutoff values of positive lymph node ratio (PLNR) were decided using X-tile program. Survival was determined using the Kaplan-Meier method. Univariate and multivariate analyses were used to identify prognosticator of gastric signet ring cell carcinoma.
resultsA total of 1,884 cases were identified. 0.8 as the optimal cutoff value to separate the patients into high and low risk subsets in accordance of cancer-caused survival in SRCC patients (the number as 0.8, P<0.0001). Patients with PLNR >0.8 remained to have a poorer prognosis compared with those with PLNR <0.8 as shown by both OS (HR =2.083, 95% CI: 1.862-2.33, P<0.001) and CSS (HR =2.052, 95% CI: 1.802-2.336, P=0.014) in the multivariate cox regression model.
conclusionsPLNR is of great significance in the evaluation of prognosis for patients with SRCC.
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